About: Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies
Creator	Rosenfeld, Cheryl Belcher, Scott Flaws, Jodi Heindel, Jerrold Ho, Shuk-Mei Mao, Jiude Patisaul, Heather Prins, Gail Ricke, William Soto, Ana Thomas Zoeller, R Vom Saal, Frederick
topic	covid:1772b0f8eb233d741df5c28dab9f96fc38193f21#this
Source	Elsevier; Medline; PMC
abstract	“Consortium Linking Academic and Regulatory Insights on BPA Toxicity” (CLARITY-BPA) was a comprehensive “industry-standard” Good Laboratory Practice (GLP)-compliant 2-year chronic exposure study of bisphenol A (BPA) toxicity that was supplemented by hypothesis-driven independent investigator-initiated studies. The investigator-initiated studies were focused on integrating disease-associated, molecular, and physiological endpoints previously found by academic scientists into an industry standard guideline-compliant toxicity study. Thus, the goal of this collaboration was to provide a more comprehensive dataset upon which to base safety standards and to determine whether industry-standard tests are as sensitive and predictive as molecular and disease-associated endpoints. The goal of this report is to integrate the findings from the investigator-initiated studies into a comprehensive overview of the observed impacts of BPA across the multiple organs and systems analyzed. For each organ system, we provide the rationale for the study, an overview of methodology, and summarize major findings. We then compare the results of the CLARITY-BPA studies across organ systems with the results of previous peer-reviewed studies from independent labs. Finally, we discuss potential influences that contributed to differences between studies. Developmental exposure to BPA can lead to adverse effects in multiple organs systems, including the brain, prostate gland, urinary tract, ovary, mammary gland, and heart. As published previously, many effects were at the lowest dose tested, 2.5μg/kg /day, and many of the responses were non-monotonic. Because the low dose of BPA affected endpoints in the same animals across organs evaluated in different labs, we conclude that these are biologically – and toxicologically – relevant.
has issue date	2020-07-16(xsd:dateTime)
bibo:doi	10.1016/j.reprotox.2020.05.014
bibo:pmid	32682780
has license	no-cc
sha1sum (hex)	1772b0f8eb233d741df5c28dab9f96fc38193f21
schema:url	https://doi.org/10.1016/j.reprotox.2020.05.014
resource representing a document's title	Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies
has PubMed Central identifier	PMC7365109
has PubMed identifier	32682780
schema:publication	Reprod Toxicol
resource representing a document's body	covid:1772b0f8eb233d741df5c28dab9f96fc38193f21#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/1772b0f8eb233d741df5c28dab9f96fc38193f21
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