About: The Role of Complement in Transfusion-Related Acute Lung Injury

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Role of Complement in Transfusion-Related Acute Lung Injury
Creator	Jongerius, Ilse Kapur, Rick Porcelijn, Leendert Semple, John Van Beek, Anna Van Der Schoot, Ellen Vlaar, Alexander
source	Elsevier; Medline; PMC
abstract	Abstract Transfusion-related acute lung injury (TRALI) is a life-threatening complication of acute respiratory distress occurring within 6 hours of blood transfusion. TRALI is one of the leading causes of transfusion-related fatalities and specific therapies are unavailable. Neutrophils are recognized as the major pathogenic cells, whereas T regulatory cells and dendritic cells appear to be important for protection against TRALI. The pathogenesis, however, is complex and incompletely understood. It is frequently postulated that the complement system plays an important role in the TRALI pathogenesis. In this article, we assess the evidence regarding the involvement of complement in TRALI from both human and animal studies. We hypothesize about the potential connection between the complement system and neutrophils in TRALI. Additionally, we draw parallels between TRALI and other acute pulmonary disorders of acute lung injury and acute respiratory distress syndrome regarding the involvement of complement. We conclude that, even though a role for complement in the TRALI pathogenesis seems plausible, studies investigating the role of complement in TRALI are remarkably limited in number and also present conflicting findings. Different types of TRALI animal models, diverse experimental conditions, and the composition of the gastrointestinal microbiota may perhaps all be factors which contribute to these discrepancies. More systematic studies are warranted to shed light on the contribution of the complement cascade in TRALI. The underlying clinical condition of the patient, which influences the susceptibility to TRALI, as well as the transfusion factor (antibody-mediated vs non–antibody-mediated), will be important to take into consideration when researching the contribution of complement. This should significantly increase our understanding of the role of complement in TRALI and may potentially result in promising new treatment strategies.
has issue date	2019-10-31(xsd:dateTime)
bibo:doi	10.1016/j.tmrv.2019.09.002
bibo:pmid	31676221
has license	els-covid
sha1sum (hex)	17888e53565c37dfcfaba4a8fb0919fe134bfb20
schema:url	https://doi.org/10.1016/j.tmrv.2019.09.002
resource representing a document's title	The Role of Complement in Transfusion-Related Acute Lung Injury
has PubMed Central identifier	PMC7127679
has PubMed identifier	31676221
schema:publication	Transfusion Medicine Reviews
resource representing a document's body	covid:17888e53565c37dfcfaba4a8fb0919fe134bfb20#body_text
is schema:about of	named entity 'COMPLEMENT' named entity 'leading' named entity 'TRALI' named entity 'pulmonary' named entity 'Injury' named entity 'INVESTIGATING' named entity 'LIMITED' named entity 'NEUTROPHILS' named entity 'INVOLVEMENT' named entity 'UNDERSTOOD' named entity 'EVIDENCE' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'NEW' named entity 'BLOOD TRANSFUSION' named entity 'PROTECTION' named entity 'ASSESS' named entity 'STRATEGIES' named entity 'STUDIES' named entity 'GASTROINTESTINAL' named entity 'PATHOGENIC' named entity 'PRESENT' named entity 'DISCREPANCIES' named entity 'COMPLEMENT CASCADE' named entity 'T REGULATORY CELLS' named entity 'LIGHT' named entity 'LIFE' named entity 'COMPLICATION' named entity 'CONTRIBUTE ' named entity 'DENDRITIC CELLS' named entity 'ANIMAL MODELS' named entity 'OUR' named entity 'IS A' named entity 'COMPOSITION' named entity 'MEDIATED' named entity 'TRALI' named entity 'LEADING' named entity 'UNDERLYING' named entity 'PATHOGENESIS' covid:arg/17888e53565c37dfcfaba4a8fb0919fe134bfb20 named entity 'CONCLUDE' named entity 'CONSIDERATION' named entity 'SPECIFIC' named entity 'COMPLEMENT SYSTEM' named entity 'CONDITION' named entity 'FREQUENTLY' named entity 'ANIMAL STUDIES' named entity 'FACTOR' named entity 'CONTRIBUTION' named entity 'POTENTIAL' named entity 'TRANSFUSION-RELATED ACUTE LUNG INJURY' named entity 'FINDINGS' named entity 'APPEAR' named entity 'THESE' named entity 'HUMAN' named entity 'COMPLEX' named entity 'EXPERIMENTAL CONDITIONS' named entity 'ANTIBODY' named entity 'UNAVAILABLE' named entity 'COMPLEMENT' named entity 'CLINICAL' named entity 'IMPORTANT' named entity 'TO TAKE' named entity 'ROLE' named entity 'MICROBIOTA' named entity 'ARTICLE' named entity 'TRANSFUSION-RELATED ACUTE LUNG INJURY' named entity 'SUSCEPTIBILITY' named entity 'THERAPIES' named entity 'TREATMENT' named entity 'CONNECTION' named entity 'PLAYS' named entity 'ACUTE' named entity 'TRANSFUSION' named entity 'PULMONARY DISORDERS' named entity 'ACUTE LUNG INJURY'

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