About: Insulin Degrading Enzyme Induces a Conformational Change in Varicella-Zoster Virus gE, and Enhances Virus Infectivity and Stability

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About: Insulin Degrading Enzyme Induces a Conformational Change in Varicella-Zoster Virus gE, and Enhances Virus Infectivity and Stability Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Insulin Degrading Enzyme Induces a Conformational Change in Varicella-Zoster Virus gE, and Enhances Virus Infectivity and Stability
Creator	Ali, M Li, Q Wang, K Hamel, F Sayre, D
Source	Medline; PMC
abstract	Varicella-zoster virus (VZV) glycoprotein E (gE) is essential for virus infectivity and binds to a cellular receptor, insulin-degrading enzyme (IDE), through its unique amino terminal extracellular domain. Previous work has shown IDE plays an important role in VZV infection and virus cell-to-cell spread, which is the sole route for VZV spread in vitro. Here we report that a recombinant soluble IDE (rIDE) enhances VZV infectivity at an early step of infection associated with an increase in virus internalization, and increases cell-to-cell spread. VZV mutants lacking the IDE binding domain of gE were impaired for syncytia formation and membrane fusion. Pre-treatment of cell-free VZV with rIDE markedly enhanced the stability of the virus over a range of conditions. rIDE interacted with gE to elicit a conformational change in gE and rendered it more susceptible to proteolysis. Co-incubation of rIDE with gE modified the size of gE. We propose that the conformational change in gE elicited by IDE enhances infectivity and stability of the virus and leads to increased fusogenicity during VZV infection. The ability of rIDE to enhance infectivity of cell-free VZV over a wide range of incubation times and temperatures suggests that rIDE may be useful for increasing the stability of varicella or zoster vaccines.
has issue date	2010-06-25(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0011327
bibo:pmid	20593027
has license	cc0
sha1sum (hex)	17a5e67e3855ae5fa7d1a711f3249b6813c28386
schema:url	https://doi.org/10.1371/journal.pone.0011327
resource representing a document's title	Insulin Degrading Enzyme Induces a Conformational Change in Varicella-Zoster Virus gE, and Enhances Virus Infectivity and Stability
has PubMed Central identifier	PMC2892511
has PubMed identifier	20593027
schema:publication	PLoS One
resource representing a document's body	covid:17a5e67e3855ae5fa7d1a711f3249b6813c28386#body_text
is schema:about of	named entity 'CHANGE IN' named entity 'VIRUS INFECTIVITY' named entity 'vaccines' named entity 'virus' named entity 'infectivity' named entity 'step' named entity 'times' named entity 'membrane fusion' named entity 'amino terminal' named entity 'varicella' named entity 'enhance' named entity 'RIDE' named entity 'INFECTION' named entity 'CHANGE IN' named entity 'PRE' named entity 'VARICELLA' named entity 'CELLULAR' named entity 'IDE' named entity 'WIDE' named entity 'INCREASED' named entity 'USEFUL' named entity 'ABILITY' named entity 'FORMATION' named entity 'VZV' named entity 'HERE' named entity 'MUTANTS' named entity 'ASSOCIATED WITH' named entity 'SPREAD' named entity 'ENHANCED' named entity 'DOMAIN' named entity 'SIZE' named entity 'ESSENTIAL' named entity 'ENZYME' named entity 'ENHANCE' named entity 'ELICITED BY' named entity 'STABILITY' named entity 'UNIQUE' named entity 'ENZYME' named entity 'PROTEOLYSIS' named entity 'EXTRACELLULAR DOMAIN' named entity 'INTERACTED' named entity 'TIMES' named entity 'TEMPERATURES' named entity 'RECEPTOR' named entity 'RECOMBINANT' named entity 'INCUBATION' named entity 'TREATMENT' named entity 'IMPORTANT' named entity 'INSULIN' named entity 'VARICELLA-ZOSTER VIRUS' named entity 'LACKING' named entity 'IN VITRO' named entity 'RANGE' named entity 'CONDITIONS' named entity 'INCREASING' named entity 'MODIFIED' named entity 'SOLE' named entity 'ITS' named entity 'MAY BE' named entity 'PREVIOUS' named entity 'VIRUS' named entity 'INFECTIVITY' named entity 'PLAYS' named entity 'STEP' named entity 'SYNCYTIA' named entity 'MEMBRANE FUSION' named entity 'INCREASE' named entity 'VARICELLA-ZOSTER VIRUS' named entity 'CELL' named entity 'BINDS' named entity 'VIRUS INFECTIVITY' named entity 'MARKEDLY' named entity 'BINDING' named entity 'FREE' named entity 'EARLY' named entity 'ROUTE' named entity 'VIRUS INTERNALIZATION'

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