About: Influence of immune aging on vaccine responses

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Influence of immune aging on vaccine responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influence of immune aging on vaccine responses
Creator	Calif, Weyand, Cornelia Alto, Palo Goronzy, J Gustafson, Claire Kim, Chulwoo Org, J€
Source	Elsevier; Medline; PMC
abstract	Impaired vaccine responses in older individuals are associated with alterations in both the quantity and quality of the T-cell compartment with age. As reviewed herein, the T-cell response to vaccination requires a fine balance between the generation of inflammatory effector T cells versus follicular helper T (TFH) cells that mediate high-affinity antibody production in tandem with the induction of long-lived memory cells for effective recall immunity. During aging, we find that this balance is tipped where T cells favor short-lived effector but not memory or TFH responses. Consistently, vaccine-induced antibodies commonly display a lower protective capacity. Mechanistically, multiple, potentially targetable, changes in T cells have been identified that contribute to these age-related defects, including posttranscription regulation, T-cell receptor signaling, and metabolic function. Although research into the induction of tissue-specific immunity by vaccines and with age is still limited, current mechanistic insights provide a framework for improved design of age-specific vaccination strategies that require further evaluation in a clinical setting.
has issue date	2020-05-31(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2020.03.017
bibo:pmid	32386655
has license	els-covid
sha1sum (hex)	17b41d2fb22f5f61e7e8cabf3285814d3e9cd252
schema:url	https://doi.org/10.1016/j.jaci.2020.03.017
resource representing a document's title	Influence of immune aging on vaccine responses
has PubMed Central identifier	PMC7198995
has PubMed identifier	32386655
schema:publication	Journal of Allergy and Clinical Immunology
resource representing a document's body	covid:17b41d2fb22f5f61e7e8cabf3285814d3e9cd252#body_text
is schema:about of	named entity 'current' named entity 'requires' named entity 'defects' named entity 'inflammatory' named entity 'AFFINITY' named entity 'LOWER' named entity 'LIMITED' covid:arg/17b41d2fb22f5f61e7e8cabf3285814d3e9cd252 named entity 'mechanistic' named entity 'immunity' named entity 'induction' named entity 'insights' named entity 'strategies' named entity 'multiple' named entity 'tissue-specific' named entity 'vaccines' named entity 'effector' named entity 'high-affinity' named entity 'T-cell receptor' named entity 'vaccine' named entity 'antibody' named entity 'vaccination' named entity 'IgM' named entity 'HIV' named entity 'Streptococcus pneumoniae' named entity 'adjuvant' named entity 'VZV' named entity 'vaccination' named entity 'memory T cells' named entity 'naive T cells' named entity 'vaccination' named entity 'germinal center' named entity 'memory T cells' named entity 'clones' named entity 'vaccine' named entity 'vaccine' named entity 'miR-21' named entity 'Influenza virus' named entity 'precursor cells' named entity 'effector cell' named entity 'antigens' named entity 'pathogens' named entity 'precursor cells' named entity 'tetanus' named entity 'VZV' named entity 'T-bet' named entity 'antibodies' named entity 'vaccine' named entity 'effector T cells' named entity 'influenza vaccination' named entity 'infection' named entity 'memory T-cell' named entity 'Japanese encephalitis' named entity 'vaccine' named entity 'Gene expression studies' named entity 'antigen' named entity 'memory cells' named entity 'cytokine' named entity 'memory T cells' named entity 'Zostavax' named entity 'immunologic memory' named entity 'Antibody' named entity 'CD8 T cells' named entity 'Japanese encephalitis' named entity 'memory T cells' named entity 'antibody' named entity 'proteostasis' named entity 'memory cells' named entity 'IL-2' named entity 'memory T cells' named entity 'memory T cells' named entity 'morbidity' named entity 'plasma cell differentiation' named entity 'T-cell' named entity 'IgA'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software