About: Exploiting lectin affinity chromatography in clinical diagnosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Exploiting lectin affinity chromatography in clinical diagnosis
Creator	Surolia, Avadhesha Satish, Posettihalli
source	Elsevier; Medline; PMC
abstract	Abstract Lectin affinity chromatography (LAC) offers a tool that aids purification of cell surface glycoconjugates in sufficient quantities so that studies addressing their structural elucidation could be carried out. It has several advantages over the conventional biochemical methods, such as immunoprecipitation and/or immunoaffinity chromatography, used for the purification of various glycoconjugates. Serial LAC (SLAC) not only helps establish the identity of a glycoprotein or allows purification of a glycoprotein to homogeneity from among a mixture of glycoproteins, but it also successfully resolves the microheterogeneity in these glycoproteins, which is an otherwise impracticable problem to address. Specific cases of the altered expression and maintenance of microheterogeneity of some of the glycoproteins in pathological conditions vis a vis during normal biology are presented. The application of LAC in (i) itself, (ii) a serial fashion, and (iii) conjunction with other techniques such as two-dimensional electrophoresis, capillary electrophoresis, mass spectrometry, etc. in the diagnosis of certain pathological conditions, and the possibility of using this knowledge in designing treatments for various diseases, is discussed.
has issue date	2001-10-30(xsd:dateTime)
bibo:doi	10.1016/s0165-022x(01)00224-x
bibo:pmid	11694306
has license	els-covid
sha1sum (hex)	17d1e232bd45170b9d3f736306a642b5aa93921e
schema:url	https://doi.org/10.1016/s0165-022x%2801%2900224-x
resource representing a document's title	Exploiting lectin affinity chromatography in clinical diagnosis
has PubMed Central identifier	PMC7130260
has PubMed identifier	11694306
schema:publication	Journal of Biochemical and Biophysical Methods
resource representing a document's body	covid:17d1e232bd45170b9d3f736306a642b5aa93921e#body_text
is schema:about of	named entity 'tool' named entity 'mass spectrometry' named entity 'USED' named entity 'ALTERED' named entity 'APPLICATION' named entity 'MASS SPECTROMETRY' named entity 'CERTAIN' named entity 'ALLOWS' named entity 'GLYCOPROTEINS' named entity 'LAC' named entity 'TWO-DIMENSIONAL ELECTROPHORESIS' named entity 'PATHOLOGICAL' named entity 'ADDRESSING' named entity 'KNOWLEDGE' named entity 'DIAGNOSIS' named entity 'THESE' named entity 'EXPRESSION' named entity 'MIXTURE' named entity 'STRUCTURAL' named entity 'COULD BE' named entity 'IDENTITY' named entity 'TECHNIQUES' named entity 'CONDITIONS' named entity 'ETC.' named entity 'ESTABLISH' named entity 'SPECIFIC' named entity 'ADDRESS' named entity 'FASHION' named entity 'SUFFICIENT' named entity 'TREATMENTS' named entity 'AIDS' named entity 'USING' named entity 'MAINTENANCE' named entity 'CASES' named entity 'TOOL' named entity 'HELPS' named entity 'LECTIN AFFINITY CHROMATOGRAPHY' named entity 'QUANTITIES' named entity 'BIOCHEMICAL' named entity 'HOMOGENEITY' named entity 'VARIOUS' named entity 'VIS' named entity 'III' named entity 'CLINICAL DIAGNOSIS' named entity 'CELL SURFACE' named entity 'CARRIED' named entity 'GLYCOCONJUGATES' named entity 'IMMUNOPRECIPITATION' named entity 'STUDIES' named entity 'BIOLOGY' named entity 'PURIFICATION' named entity 'IMMUNOAFFINITY CHROMATOGRAPHY' named entity 'CAPILLARY ELECTROPHORESIS' named entity 'PRESENTED' named entity 'PROBLEM' named entity 'THEIR' named entity 'DISEASES' named entity 'LECTIN AFFINITY CHROMATOGRAPHY' named entity 'METHODS' named entity 'SERIAL' named entity 'CONJUNCTION' named entity 'GLYCOPROTEIN' named entity 'NORMAL %' named entity 'CONVENTIONAL' named entity 'BUT' covid:arg/17d1e232bd45170b9d3f736306a642b5aa93921e named entity 'identity' named entity 'mixture' named entity 'purification' named entity 'homogeneity' named entity 'problem' named entity 'advantages' named entity 'cell' named entity 'address' named entity 'glycoprotein' named entity 'pathological conditions' named entity 'structural elucidation' named entity 'glycoprotein' named entity 'pathological conditions' named entity 'immunoprecipitation'

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