About: Virologic and clinical characteristics for prognosis of severe COVID-19: a retrospective observational study in Wuhan, China

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About: Virologic and clinical characteristics for prognosis of severe COVID-19: a retrospective observational study in Wuhan, China Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Virologic and clinical characteristics for prognosis of severe COVID-19: a retrospective observational study in Wuhan, China
Creator	Li, Min Xiong, Zeng Huang, Yan Fan, Xue-Gong Tang, Tao Song, Yang Chen, Jiang-Hai Chen, Jianghai Fu, Sha Fu, Xiao-Yu Jiang, Tie-Jian Li, Sha-Ling Long, Hui-Bao Ma, Jing-Dong Ouyang, Yi Pan, Qian, Zhao-Xin Sha, Xin-Ping Tan, De-Ming Xiao, Li-Zhi Zhang, Chun-Hu Zheng, Yi-Xiang
Source	MedRxiv
abstract	Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has progressed to a pandemic associated with substantial morbidity and mortality. The WHO and the United States Center for Disease Control and Prevention (CDC) have issued interim clinical guidance for management of patients with confirmed coronavirus disease (COVID-19), but there is limited data on the virologic and clinical characteristics for prognosis of severe COVID-19. Methods: A total of 50 patients with severe COVID-19 were divided into good and poor recovery groups. The dynamic viral shedding and serological characteristics of SARS-CoV-2 were explored. The risk factors associated with poor recovery and lung lesion resolutions were identified. In addition, the potential relationships among the viral shedding, the pro-inflammatory response, and lung lesion evolutions were characterized. Results: A total of 58% of the patients had poor recovery and were more likely to have a prolonged interval of viral shedding. The longest viral shedding was 57 days after symptom onset. Older age, hyperlipemia, hypoproteinemia, corticosteroid therapy, consolidation on chest computed-tomography (CT), and prolonged SARS-CoV-2 IgM positive were all associated with poor recovery. Additionally, the odds of impaired lung lesion resolutions were higher in patients with hypoproteinemia, hyperlipemia, and elevated levels of IL-4 and ferritin. Finally, viral shedding and proinflammatory responses were closely correlated with lung lesion evolutions on chest CT. Conclusions Patients with severe COVID-19 have prolonged SARS-CoV-2 infection and delayed intermittent viral shedding. Older age, hyperlipemia, hypoproteinemia, corticosteroid usage, and prolonged SARS-CoV-2 IgM positive might be utilized as predicative factors for the patients with poor recovery.
has issue date	2020-04-06(xsd:dateTime)
bibo:doi	10.1101/2020.04.03.20051763
has license	medrxiv
sha1sum (hex)	17de28ebcf5e84031aec3acd10e45e62bc14f594
schema:url	https://doi.org/10.1101/2020.04.03.20051763
resource representing a document's title	Virologic and clinical characteristics for prognosis of severe COVID-19: a retrospective observational study in Wuhan, China
resource representing a document's body	covid:17de28ebcf5e84031aec3acd10e45e62bc14f594#body_text
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