About: Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth
Creator	Borrow, Persephone Liao, Hua-Xin Hwang, Kwan-Ki Lee, Ji-Yeun Haynes, Barton Fire, Andrew Moody, M Bonsignori, Mattia Boyd, Scott Hoh, Ramona Jackson, Katherine Joshi, Shilpa Pedroza-Pacheco, Isabela Roskin, Krishna
Source	PMC
abstract	A goal of HIV vaccine development is to elicit antibodies with neutralizing breadth. Broadly neutralizing antibodies (bNAbs) to HIV often have unusual sequences with long heavy-chain complementarity-determining region loops, high somatic mutation rates and polyreactivity. A subset of HIV-infected individuals develops such antibodies, but it is unclear whether this reflects systematic differences in their antibody repertoires or is a consequence of rare stochastic events involving individual clones. We sequenced antibody heavy-chain repertoires in a large cohort of HIV-infected individuals with bNAb responses or no neutralization breadth and uninfected controls, identifying consistent features of bNAb repertoires, encompassing thousands of B cell clones per individual, with correlated T cell phenotypes. These repertoire features were not observed during chronic cytomegalovirus infection in an independent cohort. Our data indicate that the development of numerous B cell lineages with antibody features associated with autoreactivity may be a key aspect in the development of HIV neutralizing antibody breadth.
has issue date	2020-01-20(xsd:dateTime)
bibo:doi	10.1038/s41590-019-0581-0
bibo:pmid	31959979
has license	no-cc
sha1sum (hex)	1839d344ed15c61f2c26ae4d12cbdd617c7d0b5f
schema:url	https://doi.org/10.1038/s41590-019-0581-0
resource representing a document's title	Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth
has PubMed Central identifier	PMC7223457
has PubMed identifier	31959979
schema:publication	Nat Immunol
resource representing a document's body	covid:1839d344ed15c61f2c26ae4d12cbdd617c7d0b5f#body_text
is schema:about of	named entity 'Broadly' named entity 'rare' named entity 'development' named entity 'clones' named entity 'ELICIT' named entity 'SUBSET' named entity 'LONG' named entity 'SEQUENCES' named entity 'BREADTH' named entity 'HEAVY-CHAIN' named entity 'THEIR' named entity 'HIV VACCINE' named entity 'INFECTED' named entity 'antibody' named entity 'stochastic' named entity 'complementarity-determining region' named entity 'HIV vaccine' named entity 'heavy-chain' named entity 'antibodies' named entity 'heavy-chain' named entity 'clones' named entity 'complementarity-determining region' named entity 'antibody' named entity 'neutralizing antibody' named entity 'nucleotide' named entity 'germline' named entity 'co-clustering' named entity 'Foxp3' named entity 'IGHV' named entity 'PD-1' named entity 'CD4' named entity 'IGHV' named entity 'gp120' named entity 'phenotyping' named entity 'CMV' named entity 'Antibodies' named entity 'antibody' named entity 'self-antigens' named entity 'CTLA-4' named entity 'HIV' named entity 'memory B cells' named entity 'HBV' named entity 'herpesvirus' named entity 'IgG' named entity 'epitope' named entity 'individuals with HIV' named entity 'blood donors' named entity 'antigen' named entity 'pseudovirus' named entity 'heavy-chain' named entity 'isotype' named entity 'IGH' named entity 'clonality' named entity 'SHM' named entity 'SHM' named entity 'IGH' named entity 'IgG' named entity 'IGH' named entity 'Sequence data' named entity 'V(D)J recombination' named entity 'antibodies' named entity 'constant region' named entity 'heavy-chain' named entity 'complementarity-determining region 3' named entity 'HIV infection' named entity 'diagnostic purposes' named entity 'antibody isotype' named entity 'HIV envelope'

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