About: Kidney transplant patients with SARS‐CoV‐2 infection: the brescia renal COVID task force experience

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About: Kidney transplant patients with SARS‐CoV‐2 infection: the brescia renal COVID task force experience Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Kidney transplant patients with SARS‐CoV‐2 infection: the brescia renal COVID task force experience
Creator	Alberici, Federico Bossini, Nicola Delbarba, Elisa Econimo, Laura Gaggiotti, Mario Maffei, Camilla Malberti, Fabio Manenti, Chiara Pola, Alessandra Possenti, Stefano Scolari, Francesco Valerio, Francesca Affatato, Stefania Depetri, Giorgio Moscato, Marianna Pasquali, Stefano Pecchini, Paola Salviani, Chiara Terlizzi, Vincenzo Tonoli, Michela Viola, Fabio Zambetti, Nicole
Source	Medline; PMC
abstract	The outcome of kidney transplant patients with SARS‐CoV‐2 infection is still unclear. Here we describe the clinical characteristics, disease outcome and risk factors for ARDS and death of a cohort of 53 kidney transplant patients with COVID‐19. 8/53 have been handled as outpatients due to mild disease, on average with immunosuppression reduction and the addiction of hydroxychloroquine and azithromycin; no patients required admission, developed ARDS or died. 45/53 required admission due to severe symptoms: this cohort has been managed with immunosuppression withdrawal, methylprednisolone 16 mg/day, hydroxychloroquine and antiviral drugs. Dexamethasone and tocilizumab were considered in case of ARDS. 33% of the patients developed AKI, 60% ARDS and 33% died. In this group, thrombocytopenia was associated to ARDS while lymphopenia at the baseline, higher D‐dimer and lack of CRP reduction with risk of death. In the overall population, dyspnoea was associated with the risk of ARDS while age older than 60 years and dyspnoea with the risk of death with only a trend towards an increased risk of death for patients on tacrolimus. In conclusion, SARS‐CoV‐2 infection may have a variable outcome in renal transplant patients, with higher risk of ARDS and death in the ones requiring admission.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1111/ajt.16176
bibo:pmid	32627319
has license	no-cc
sha1sum (hex)	184f9368de12a065b3d8bb327ebda8eb224fb9b6
schema:url	https://doi.org/10.1111/ajt.16176
resource representing a document's title	Kidney transplant patients with SARS‐CoV‐2 infection: the brescia renal COVID task force experience
has PubMed Central identifier	PMC7361317
has PubMed identifier	32627319
schema:publication	Am J Transplant
resource representing a document's body	covid:184f9368de12a065b3d8bb327ebda8eb224fb9b6#body_text
is schema:about of	named entity 'disease' named entity 'case' named entity 'severe' named entity 'PATIENTS' covid:arg/184f9368de12a065b3d8bb327ebda8eb224fb9b6 named entity 'patients' named entity 'mild' named entity 'disease' named entity 'died' named entity 'immunosuppression' named entity 'immunosuppression' named entity 'hydroxychloroquine' named entity 'clinical characteristics' named entity 'ARDS' named entity 'kidney transplant' named entity 'disease outcome' named entity 'tocilizumab' named entity 'ARDS' named entity 'CRP' named entity 'azithromycin' named entity 'immunosuppression' named entity 'ARDS' named entity 'risk factors' named entity 'D-dimer' named entity 'INFECTION' named entity 'dexamethasone' named entity 'clinical characteristics' named entity 'glucocorticoid' named entity 'risk factor' named entity 'ICU' named entity 'SARS-CoV-2' named entity 'CRP' named entity 'COVID' named entity 'fever' named entity 'fatality rate' named entity 'chest x-ray' named entity 'ICU' named entity 'ARDS' named entity 'KTx' named entity 'evolution' named entity 'COVID-19' named entity 'protease inhibitors' named entity 'ICU' named entity 'risk factor' named entity 'ARDS' named entity 'KTx' named entity 'dyspnoea' named entity 'COVID-19' named entity 'hydroxychloroquine' named entity 'risk factor' named entity 'American Journal of Transplantation' named entity 'kidney transplant' named entity 'anti-inflammatory' named entity 'kidney transplant' named entity 'Italy' named entity '3, 4' named entity 'potency' named entity 'equivalent dose' named entity 'Antiviral therapy' named entity 'ARDS'

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