About: Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry
Creator	Al-Herz, Waleed Essa, Sahar Ruuskanen, Olli Aksu, Guzide
Source	Medline; PMC
abstract	Objective: To present the frequency and spectrum of viral infections in primary immunodeficient children. Methods: The data was obtained from the Kuwait National Primary Immunodeficiency Disorders (PIDs) Registry during the period of 2004-2018. Results: A total of 274 PID children were registered in KNPIDR during the study period with predominance of immunodeficiencies affecting cellular and humoral immunity, followed by combined immunodeficiencies with associated syndromic features and diseases of immune dysregulation. Overall infectious complications affected 82.4% of the patients, and viral infections affected 31.7% of the registered patients. Forty-five patients (16.4%) developed viral infections caused by at least 2 organisms, among those 20 patients were affected by three or more viral infections. There was a statistically significant association between viral infections and PID category. However, there was no statistically significant association between viral infections and gender or the patients' onset age. There was a total of 170 viral infections during the study period and the causes of these infections were predominated by CMV (22.2%), adenovirus (11.7%), EBV (11.1%), and enteroviruses (7.4%). CMV and parainfluenza infections were more common in the group of immunodeficiencies affecting cellular and humoral immunity while EBV and human papilloma virus (HPV) were more common in the immune dysregulation group and combined immunodeficiencies with associated syndromic features, respectively. The most common presentation was viremia (28.8%) followed by pneumonia (28.2%) and skin infections (17.6%). The most common causes of viremia were CMV followed by adenovirus and EBV, while the most common organisms causing pneumonia were CMV followed by rhinovirus and parainfluenza. There were 80 deaths among the registered patients, 10% were caused by viral infections. Conclusions: Viral infections are common in PIDs and result into a wide-range of clinical manifestations causing significant morbidity and mortality.
has issue date	2019-05-29(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.01231
bibo:pmid	31191561
has license	cc-by
sha1sum (hex)	1894cac8794748c11482c059bc5a2c6d4f1e9527
schema:url	https://doi.org/10.3389/fimmu.2019.01231
resource representing a document's title	Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry
has PubMed Central identifier	PMC6549382
has PubMed identifier	31191561
schema:publication	Front Immunol
resource representing a document's body	covid:1894cac8794748c11482c059bc5a2c6d4f1e9527#body_text
is schema:about of	named entity 'PRESENT' named entity 'CHILDREN' named entity 'IMMUNODEFICIENT' named entity 'PRIMARY' named entity 'CHILDREN' named entity 'REPORT' named entity 'VIRAL INFECTIONS' named entity 'NATIONAL REGISTRY' named entity 'FREQUENCY' named entity 'SPECTRUM' named entity 'IMMUNODEFICIENT' named entity 'VIRAL INFECTIONS' named entity 'OBJECTIVE' named entity 'SPECTRUM' named entity 'PRIMARY' covid:arg/1894cac8794748c11482c059bc5a2c6d4f1e9527 named entity 'Viral Infections' named entity 'immunodeficiencies' named entity 'signs and symptoms' named entity 'complement' named entity 'enterovirus' named entity 'intravenous immunoglobulins' named entity 'cerebrospinal fluid' named entity 'hematopoietic stem cell transplant' named entity 'stomatitis' named entity 'genotype-phenotype' named entity 'Enteritis' named entity 'CMV' named entity 'Germany' named entity 'Sapovirus' named entity 'adenovirus' named entity 'influenza' named entity 'HHV-6' named entity 'herpesvirus 6' named entity 'Adenovirus' named entity 'gastrointestinal' named entity 'Health Sciences' named entity 'molluscum contagiosum' named entity 'Viral infections' named entity 'vaccination schedule' named entity 'viral infection' named entity 'chicken pox' named entity 'HIV' named entity 'BTK' named entity 'PID' named entity 'combined immunodeficiencies' named entity 'Colitis' named entity 'viral infections' named entity 'malignancies' named entity 'excretion' named entity 'nasopharyngeal aspirate' named entity 'intravenous immunoglobulins' named entity 'immunodeficiencies' named entity 'hematopoietic stem cell transplants' named entity 'CMV' named entity 'CMV' named entity 'IBM' named entity 'HSCT' named entity 'Adenovirus' named entity 'combined immunodeficiencies' named entity 'skin infections' named entity 'HSCT' named entity 'OPV' named entity 'antibody response' named entity 'viral infections' named entity 'human papilloma virus' named entity 'Kuwait' named entity 'viremia' named entity 'EBV' named entity 'Norovirus' named entity 'HPV' named entity 'Inborn Errors' named entity 'thermocycler' named entity 'HSV' named entity 'complement' named entity 'CSF' named entity 'OPV' named entity 'Enterovirus'

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