About: Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis

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About: Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis
Creator	Tschudin-Sutter, Sarah Pargger, Hans Borgwardt, Karsten Bourguignon, Lucie Egli, Adrin Jutzeler, Catherine Rieck, Bastian Tong, Bobo Walter, Matthias Weis, Caroline Wong, Cyrus Bourguignon Bsc, Lucie Tong Mph, Bobo Weis Msc, Wong Bsc, Cyrus
source	Elsevier; Medline; PMC
abstract	INTRODUCTION: Since December 2019, a novel coronavirus (SARS-CoV-2) has triggered a world-wide pandemic with an enormous medical and societal-economic toll. Thus, our aim was to gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with coronavirus disease 2019 (COVID-19). METHODS: EMBASE, PubMed/Medline, Scopus, and Web of Science were searched for studies published in any language between December 1(st), 2019 and March 28(th). Original studies were included if the exposure of interest was an infection with SARS-CoV-2 or confirmed COVID-19. The primary outcome was the risk ratio of comorbidities, clinical signs and symptoms, imaging features, treatments, outcomes, and complications associated with COVID-19 morbidity and mortality. We performed random-effects pairwise meta-analyses for proportions and relative risks, I(2), Tau(2), and Cochrane Q, sensitivity analyses, and assessed publication bias. RESULTS: 148 studies met the inclusion criteria for the systematic review and meta-analysis with 12’149 patients (5’739 female) and a median age of 47.0 [35.0-64.6] years. 617 patients died from COVID-19 and its complication. 297 patients were reported as asymptomatic. Older age (SMD: 1.25 [0.78- 1.72]; p < 0.001), being male (RR = 1.32 [1.13-1.54], p = 0.005) and pre-existing comorbidity (RR = 1.69 [1.48-1.94]; p < 0.001) were identified as risk factors of in-hospital mortality. The heterogeneity between studies varied substantially (I(2); range: 1.5-98.2%). Publication bias was only found in eight studies (Egger’s test: p < 0.05). CONCLUSIONS: Our meta-analyses revealed important risk factors that are associated with severity and mortality of COVID-19.
has issue date	2020-08-04(xsd:dateTime)
bibo:doi	10.1016/j.tmaid.2020.101825
bibo:pmid	32763496
has license	no-cc
sha1sum (hex)	18b6e832d861acc5faf925232ea60fe37f872569
schema:url	https://doi.org/10.1016/j.tmaid.2020.101825
resource representing a document's title	Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis
has PubMed Central identifier	PMC7402237
has PubMed identifier	32763496
schema:publication	Travel Med Infect Dis
resource representing a document's body	covid:18b6e832d861acc5faf925232ea60fe37f872569#body_text
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