About: ZIKV Infection Induces an Inflammatory Response but Fails to Activate Types I, II, and III IFN Response in Human PBMC

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About: ZIKV Infection Induces an Inflammatory Response but Fails to Activate Types I, II, and III IFN Response in Human PBMC Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ZIKV Infection Induces an Inflammatory Response but Fails to Activate Types I, II, and III IFN Response in Human PBMC
Creator	Ippolito, Giuseppe Agrati, Chiara Biava, Mirella Bordi, Licia Bordoni, Veronica Caglioti, Claudia Castilletti, Concetta Colavita, Francesca Iannetta, Marco Lalle, Eleonora Quartu, Serena Capobianchi, Maria
Source	PMC
abstract	The recent epidemic in the Americas caused by Zika virus (ZIKV), Asian lineage, spurred the research towards a better understanding of how ZIKV infection affects the host immune response. The aim of this study was to evaluate the effects of Asian and East African ZIKV strain infection on the induction of IFN and proinflammatory and Th2 cytokines in human PBMC. We reported a slight modulation of type II IFN in PBMC exposed to Asian strain, but not to African strain, and a complete lack of type I and III IFN induction by both strains, suggesting the ability of ZIKV to evade the IFN system not only inhibiting the antiviral IFN response but also IFN production. Moreover, we highlighted a polyfunctional immune activation only in PBMC exposed to Asian strain, due to the induction of an inflammatory profile (IL-6, IL-8) and of a Th9 (IL-9) response. Overall, our data show a different ability of the ZIKV Asian strain, with respect to the African strain, to activate host immune response that may have pathogenetic implications for virus spread in vivo, including mother-to-child transmission and induction of severe fetal complications, as birth defects and neurological disorders.
has issue date	2018-06-03(xsd:dateTime)
bibo:doi	10.1155/2018/2450540
bibo:pmid	29967565
has license	cc-by
sha1sum (hex)	18d519cf1ea884ddf381067f0733c18d8ad94c7a
schema:url	https://doi.org/10.1155/2018/2450540
resource representing a document's title	ZIKV Infection Induces an Inflammatory Response but Fails to Activate Types I, II, and III IFN Response in Human PBMC
has PubMed Central identifier	PMC6008743
has PubMed identifier	29967565
schema:publication	Mediators Inflamm
resource representing a document's body	covid:18d519cf1ea884ddf381067f0733c18d8ad94c7a#body_text
is schema:about of	named entity 'IFN' named entity 'ability' named entity 'activate' named entity 'exposed' named entity 'slight' named entity 'type II' named entity 'INFECTION' named entity 'REPORTED' named entity 'AFRICAN' named entity 'CYTOKINES' named entity 'MOTHER-TO-CHILD TRANSMISSION' named entity 'IN VIVO' named entity 'IMMUNE ACTIVATION' named entity 'LACK' named entity 'HUMAN' named entity 'SLIGHT' named entity 'IFN' named entity 'ACTIVATE' named entity 'INDUCTION' named entity 'SYSTEM' named entity 'DUE TO' named entity 'VIRUS' named entity 'CAUSED BY' named entity 'ASIAN' named entity 'PRODUCTION' named entity 'MAY HAVE' named entity 'RECENT' named entity 'MODULATION' named entity 'TH2' named entity 'BIRTH DEFECTS' named entity 'PBMC' named entity 'FETAL COMPLICATIONS' named entity 'RESPONSE' named entity 'NEUROLOGICAL DISORDERS' named entity 'ABILITY' named entity 'INHIBITING' named entity 'RESPECT' named entity 'LINEAGE' named entity 'EXPOSED TO' named entity 'PROFILE' named entity 'DATA' named entity 'SPREAD' named entity 'HUMAN' named entity 'ANTIVIRAL' named entity 'SEVERE' named entity 'EFFECTS' named entity 'EVALUATE' named entity 'DIFFERENT' named entity 'STRAIN' named entity 'FAILS' named entity 'TYPES' named entity 'ACTIVATE' named entity 'RESPONSE' named entity 'RESEARCH' named entity 'INFLAMMATORY RESPONSE' named entity 'BETTER' named entity 'EAST' named entity 'AIM' named entity 'BUT' named entity 'HOST IMMUNE RESPONSE' named entity 'ZIKA VIRUS' named entity 'STUDY' named entity 'INCLUDING' named entity 'STRAINS' named entity 'AMERICAS' named entity 'OVERALL' named entity 'TYPE II' named entity 'III' named entity 'COMPLETE' named entity 'HOW'

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