About: A LAIR-1 insertion generates broadly reactive antibodies against malaria variant antigens

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A LAIR-1 insertion generates broadly reactive antibodies against malaria variant antigens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A LAIR-1 insertion generates broadly reactive antibodies against malaria variant antigens
Creator	Corti, Davide Lanzavecchia, Antonio Sallusto, Federica Bianchi, Siro Bejon, Philip Marsh, Kevin Jarrossay, David Geiger, Roger Fernandez-Rodriguez, Blanca Barbieri, Sonia Bull, Peter Maina Ndungu, Francis Tan, Joshua Thathy, Vandana Wambua, Juliana Abdi, Foglierini Perez, Mathilde Fregni, Chiara Luca, Piccoli Tully, Claire
source	Medline; PMC
abstract	Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies(1–4). Although broadly reactive antibodies against these antigens could be useful as therapeutics and in vaccine design, their identification has proven elusive. Here, we report the isolation of human monoclonal antibodies that recognize erythrocytes infected by different P. falciparum isolates and opsonize these cells by binding to members of the RIFIN family. These antibodies acquired broad reactivity through a novel mechanism of insertion of a large DNA fragment between the V and DJ segments. The insert, which is both necessary and sufficient for binding to RIFINs, encodes the entire 100 amino acid collagen-binding domain of LAIR-1, an Ig superfamily inhibitory receptor encoded on chromosome 19. In each of the two donors studied, the antibodies are produced by a single expanded B cell clone and carry distinct somatic mutations in the LAIR-1 domain that abolish binding to collagen and increase binding to infected erythrocytes. These findings illustrate, with a biologically relevant example, a novel mechanism of antibody diversification by interchromosomal DNA transposition and demonstrate the existence of conserved epitopes that may be suitable candidates for the development of a malaria vaccine.
has issue date	2015-12-23(xsd:dateTime)
bibo:doi	10.1038/nature16450
bibo:pmid	26700814
has license	no-cc
sha1sum (hex)	18d51b527546f388651b7d1322d9a9538c333b61
schema:url	https://doi.org/10.1038/nature16450
resource representing a document's title	A LAIR-1 insertion generates broadly reactive antibodies against malaria variant antigens
has PubMed Central identifier	PMC4869849
has PubMed identifier	26700814
schema:publication	Nature
resource representing a document's body	covid:18d51b527546f388651b7d1322d9a9538c333b61#body_text
is schema:about of	named entity 'mechanism' named entity 'generates' named entity 'broadly' named entity 'insertion' named entity 'antigens' named entity 'SEGMENTS' named entity 'TARGETS' named entity 'MECHANISM' named entity 'PATHOGEN' named entity 'COULD BE' named entity 'THESE' named entity 'ACQUIRED IMMUNITY' named entity 'USEFUL' named entity 'FAMILY' named entity 'EXPRESSED' named entity 'THERAPEUTICS' named entity 'MALARIA' named entity 'REACTIVE' named entity 'REPORT' named entity 'MEANS' named entity 'ANTIGENS' named entity 'VARIANT' named entity 'LAIR-1' named entity 'INSERTION' named entity 'ANTIBODIES' named entity 'IDENTIFICATION' named entity 'PROVEN' named entity 'VARIABILITY' named entity 'BINDING' named entity 'HOST' named entity 'PLASMODIUM FALCIPARUM' named entity 'BUT' named entity 'ERYTHROCYTES' named entity 'ANTIGENS' named entity 'CELLS' named entity 'REACTIVE' named entity 'SURFACE' named entity 'P. FALCIPARUM' named entity 'HERE' named entity 'ISOLATION' named entity 'THEIR' named entity 'NUMBER' named entity 'HIGH' named entity 'RECOGNIZE' named entity 'INSERTION' named entity 'VACCINE DESIGN' named entity 'INFECTED' named entity 'BROAD' named entity 'POWERFUL' named entity 'ACQUIRED' named entity 'ANTIBODIES' named entity 'MEMBERS' named entity 'MALARIA' named entity 'LARGE' named entity 'REACTIVITY' named entity 'NOVEL' named entity 'MONOCLONAL ANTIBODIES' named entity 'IMPORTANT' named entity 'DNA FRAGMENT' named entity 'PROVIDE' named entity 'DIFFERENT' named entity 'ESCAPE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software