About: Application of Aptamers in Virus Detection and Antiviral Therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Application of Aptamers in Virus Detection and Antiviral Therapy
Creator	Gu, Jiaqi Mao, Lingxiang Shen, Li Wu, Jing Zou, Xinran Wu, Guanghui Banyard, Ashley Dugoni, Arthur Duzgunes, Nejat
Source	Medline; PMC
abstract	Viral infections can cause serious diseases for humans and animals. Accurate and early detection of viruses is often crucial for clinical diagnosis and therapy. Aptamers are mostly single-stranded nucleotide sequences that are artificially synthesized by an in vitro technology known as the Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Similar to antibodies, aptamers bind specifically to their targets. However, compared with antibody, aptamers are easy to synthesize and modify and can bind to a broad range of targets. Thus, aptamers are promising for detecting viruses and treating viral infections. In this review, we briefly introduce aptamer-based biosensors (aptasensors) and describe their applications in rapid detection of viruses and as antiviral agents in treating infections. We summarize available data about the use of aptamers to detect and inhibit viruses. Furthermore, for the first time, we list aptamers specific to different viruses that have been screened out but have not yet been used for detecting viruses or treating viral infections. Finally, we analyze barriers and developing perspectives in the application of aptamer-based virus detection and therapeutics.
has issue date	2019-07-03(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.01462
bibo:pmid	31333603
has license	cc-by
sha1sum (hex)	18efb24780930c0ee4343fd31b37b39ce3c3b315
schema:url	https://doi.org/10.3389/fmicb.2019.01462
resource representing a document's title	Application of Aptamers in Virus Detection and Antiviral Therapy
has PubMed Central identifier	PMC6618307
has PubMed identifier	31333603
schema:publication	Front Microbiol
resource representing a document's body	covid:18efb24780930c0ee4343fd31b37b39ce3c3b315#body_text
is schema:about of	named entity 'screened' named entity 'viruses' named entity 'Thus' named entity 'introduce' named entity 'detection' named entity 'Citation' named entity 'CITATION' named entity 'ANTIVIRAL THERAPY' named entity 'DETECTION' named entity 'DIFFERENT' named entity 'VIRAL INFECTIONS' named entity 'BASED' named entity 'SINGLE-STRANDED NUCLEOTIDE' named entity 'APPLICATION' named entity 'EASY' named entity 'USE OF' named entity 'DETECTING' named entity 'ANTIVIRAL AGENTS' named entity 'SIMILAR' named entity 'APTAMER' named entity 'TECHNOLOGY' named entity 'HAVE' named entity 'DEVELOPING' named entity 'BROAD' named entity 'TREATING' named entity 'REVIEW' named entity 'COMPARED' named entity 'LIST' named entity 'KNOWN' named entity 'CAUSE' named entity 'AVAILABLE' named entity 'THEIR' named entity 'ANTIBODIES' named entity 'SYNTHESIZE' named entity 'ANIMALS' named entity 'HUMANS' named entity 'SYNTHESIZED' named entity 'APTAMERS' named entity 'ABOUT' named entity 'DISEASES' named entity 'MODIFY' named entity 'USED' named entity 'APTAMERS' named entity 'EARLY DETECTION' named entity 'APPLICATION' named entity 'BIOSENSORS' named entity 'TO DETECT' named entity 'VIRUS DETECTION' named entity 'NUCLEOTIDE SEQUENCES' named entity 'ANTIBODY' named entity 'INTRODUCE' named entity 'BUT' named entity 'ACCURATE' named entity 'CLINICAL DIAGNOSIS' named entity 'SPECIFIC' named entity 'RANGE' named entity 'THERAPEUTICS' named entity 'TARGETS' named entity 'APPLICATIONS' named entity 'THERAPY' named entity 'VIRUS DETECTION' named entity 'INFECTIONS' named entity 'IN VITRO' named entity 'DATA' named entity 'TIME' named entity 'SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT' named entity 'BIND' named entity 'DESCRIBE' named entity 'RAPID' named entity 'VIRUSES' covid:arg/18efb24780930c0ee4343fd31b37b39ce3c3b315 named entity 'list' named entity 'rapid'

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