About: Clinical characteristics and chest CT imaging features of critically ill COVID-19 patients

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics and chest CT imaging features of critically ill COVID-19 patients
Creator	Zhang, Nan Chen, Gang Li, Yu Sun, Zhonghua Xu, Xunhua Yin, Huiming Zhou, Ling-Yan
Source	Medline; PMC
abstract	OBJECTIVES: To compare clinical, laboratory, and chest computed tomography (CT) findings in critically ill patients diagnosed with coronavirus disease 2019 (COVID-19) who survived and who died. METHODS: This retrospective study reviewed 60 critically ill patients (43 males and 17 females, mean age 64.4 ± 11.0 years) with COVID-19 pneumonia who were admitted to two different clinical centers. Their clinical and medical records were analyzed, and the chest CT images were assessed to determine the involvement of lobes and the distribution of lesions in the lungs between the patients who recovered from the illness and those who died. RESULTS: Compared with recovered patients (50/60, 83%), deceased patients (10/60, 17%) were older (mean age, 70.6 vs. 62.6 years, p = 0.044). C-reactive protein (CRP) (110.8 ± 26.3 mg/L vs 63.0 ± 50.4 mg/L, p < 0.001) and neutrophil-to-lymphocyte ratio (NLR) (18.7 ± 16.6 vs 8.4 ± 7.5, p = 0.030) were significantly elevated in the deceased as opposed to the recovered. Medial or parahilar area involvement was observed in all the deceased patients (10/10, 100%), when compared to only 54% (27/50) in the recovered. Ground-glass opacities (97%), crazy-paving pattern (92%), and air bronchogram (93%) were the most common radiological findings. There was significant difference in diabetes (p = 0.025) and emphysema (p = 0.013), and the odds ratio on a deceased patient having diabetes and emphysema was 6 times and 21 times the odds ratio on a recovered patient having diabetes and emphysema, respectively. CONCLUSIONS: Older patients with comorbidities such as diabetes and emphysema, and higher CRP and NLRs with diffuse lung involvement were more likely to die of COVID-19. KEY POINTS: • Almost all patients critically ill with COVID-19 pneumonia had five lung lobes involved. • Medial or parahilar area involvement and degree of lung involvement were more serious in the deceased patients when compared with those who recovered from treatment. • Chronic lung disease, e.g., emphysema, diabetes, and higher serum CRP and NLR characterized patients who died of COVID-19.
has issue date	2020-05-30(xsd:dateTime)
bibo:doi	10.1007/s00330-020-06955-x
bibo:pmid	32474629
has license	no-cc
sha1sum (hex)	19101de075c7377750d2b38fe496906e15c202d8
schema:url	https://doi.org/10.1007/s00330-020-06955-x
resource representing a document's title	Clinical characteristics and chest CT imaging features of critically ill COVID-19 patients
has PubMed Central identifier	PMC7260469
has PubMed identifier	32474629
schema:publication	Eur Radiol
resource representing a document's body	covid:19101de075c7377750d2b38fe496906e15c202d8#body_text
is schema:about of	named entity 'higher' named entity 'medical records' named entity 'died' named entity 'patients' named entity 'critically ill' named entity 'survived' named entity 'determine' named entity 'NLR' named entity 'diffuse' named entity 'critically ill' named entity 'HIGHER' named entity 'NEUTROPHIL' named entity 'MEAN' named entity 'RATIO' named entity 'MEDICAL RECORDS' named entity 'ASSESSED' named entity 'MALES' named entity 'DECEASED' named entity 'images' named entity 'chest' named entity 'C-reactive protein' named entity 'lung' named entity 'emphysema' named entity 'distribution' named entity 'recovered' named entity '6 times' named entity 'odds ratio' named entity 'diabetes' named entity '16.6' named entity 'COVID' named entity 'COVID' named entity 'Ground-glass opacities' named entity 'coronavirus disease 2019' named entity 'neutrophil' named entity 'odds ratio' named entity 'lungs' named entity 'Objectives' named entity 'patients' named entity 'lymphocytes' named entity 'pulmonary parenchymal' named entity 'critically ill patients' named entity 'CT image' named entity 'standard deviation' named entity 'Siemens Healthineers' named entity 'antiviral drugs' named entity 'odds ratio' named entity 'lungs' named entity 'lymph node' named entity 'lesion' named entity 'chest CT' named entity 'COVID' named entity 'COVID' named entity 'cardiothoracic' named entity 'COVID' named entity 'follow-up' named entity 'decision-making' named entity 'high fever' named entity 'CHD' named entity 'long-term' named entity 'oxygen saturation' named entity 'COVID' named entity 'critically ill' named entity 'pneumonia' named entity 'hypertension' named entity 'CRP' named entity 'SPSS' named entity 'adverse reaction' named entity 'calcification' named entity 'critically ill' named entity 'lung' named entity 'COVID-19' named entity 'COVID' named entity 'emphysema' named entity 'lung disease' named entity 'Hunan Provinces'

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