About: Positive natural selection in the evolution of human metapneumovirus attachment glycoprotein

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About: Positive natural selection in the evolution of human metapneumovirus attachment glycoprotein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Positive natural selection in the evolution of human metapneumovirus attachment glycoprotein
Creator	Padhi, Abinash Verghese, Bindhu
Source	Elsevier; Medline; PMC
abstract	Abstract Human metapneumovirus (hMPV), a newly discovered virus of the family Paramyxoviridae, has been associated with upper and lower respiratory tract infections in different age groups in many countries. The putative attachment (G) glycoprotein of this virus was previously reported to have shown more extensive nucleotide and deduced amino acid sequence polymorphism than any other genomic regions of this virus, leading to four sub-lineages. Using a maximum likelihood-based codon substitution model of sequence evolution, here we report that sequences of extracellular domain of 8 amino acid sites in lineage 1a, and 3 amino acid sites each in lineage 1b, 2a, and 2b have a higher rate of nonsynonymous substitutions (dN) than the synonymous substitutions (dS) with a posterior probability above 0.95, thus suggesting the evidence of adaptive evolution driven by Darwinian selection. Although it is unclear whether these amino acid adaptations are driven by differential immune pressure or some other factors, identification of these positively selected amino acid sites would help in better screening using epitope mapping technology to identify and localize the sites that can be recognized by the immune system. We also observed surprisingly higher nucleotide substitution rates per site, per year for each lineage of hMPV than the rates that were previously reported for the human respiratory syncytial virus, suggesting rapid evolutionary dynamics of hMPV.
has issue date	2008-02-29(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2007.08.014
bibo:pmid	17931731
has license	els-covid
sha1sum (hex)	1996f69b64707265aa7598a82d3281c4b9d7aaf6
schema:url	https://doi.org/10.1016/j.virusres.2007.08.014
resource representing a document's title	Positive natural selection in the evolution of human metapneumovirus attachment glycoprotein
has PubMed Central identifier	PMC7114232
has PubMed identifier	17931731
schema:publication	Virus Research
resource representing a document's body	covid:1996f69b64707265aa7598a82d3281c4b9d7aaf6#body_text
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