About: COVID-19 management in a UK NHS Foundation Trust with a High Consequence Infectious Diseases centre: a detailed descriptive analysis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19 management in a UK NHS Foundation Trust with a High Consequence Infectious Diseases centre: a detailed descriptive analysis
Creator	Price, David Taha, Yusri Li, Ang Sykes, Allison Duncan, Christopher Affiliations, * Capstick, Richard Schmid, Matthias Ahmed, Sajeel Alderson, Neil Baker, Kenneth Bajwa, Dalvir Barr, Andrew Brennan, Graham Burns, Matthew Cadamy, Ian Clement, Jennifer Cobb, Angela Collins, Jill Cook, Sue Cunningham, Melanie Dixon, Martin Duddy, Adam Eid, Alsafi Evans, Simon Field, Joanne Gibson, Lewis Gibbins, Christopher Gray, Margaret Guthrie, Lisa Hanrath, Aidan Harris, Elizabeth Hill, Kelly Hunt, Simon Hunter, Ewan Kerr, Stuart Kinnersley, David Lendrem, Clare Lendrem, Dennis Little, Christopher Marchitelli, Gabriella Mohammed, Omer Mountford, Anne Nuth, Kevin Pareja-Cebrian, Lucia Payne, Brendan Pelham, Sarah Platt, Ulrich Samuel, Ally Schim Van Der Loeff, Ina Schwab, Julie Speight, Nadia Stock, Jason Tee, Su Urron, Jon Walton, Sophie Welch, Andrew
Source	MedRxiv
abstract	Background: Recent large national and international cohorts describe the baseline characteristics and outcome of hospitalised patients with COVID-19, however there is little granularity to these reports. We aimed to provide a detailed description of a UK COVID-19 cohort, focusing on clinical decisions and patient journeys. Methods: We retrospectively analysed the management and 28-day outcomes of 316 consecutive adult patients with SARS-CoV-2 PCR-confirmed COVID-19 admitted to a large NHS Foundation Trust with a tertiary High Consequence Infectious Diseases centre in the North of England. Findings: Most patients were elderly (median age 75) with multiple comorbidities. One quarter were admitted from residential or nursing care. Symptoms were consistent with COVID-19, with cough, fever and/or breathlessness in 90.5% of patients. Two thirds of patients had severe disease on admission. Mortality was 81/291 (27.8%). Most deaths were anticipated; decisions to initiate respiratory support were individualised after consideration of patient wishes, premorbid frailty and comorbidities, with specialist palliative care input where appropriate. 22/291 (7.6%) patients were intubated and 11/22 (50%) survived beyond discharge. Multiple logistic regression identified age as the most significant risk factor for death (OR 1.09 [95% CI 1.06 - 1.12] per year increase, p < 0.001). Interpretation: These findings provide important clinical context to outcome data. Deaths were anticipated, occurring in patients with advance decisions on ceilings of treatment. Age was the most significant risk factor for death, confirming that demographic factors in the population are a major influence on hospital mortality rates. Funding: Funding was not required.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1101/2020.05.14.20100834
has license	medrxiv
sha1sum (hex)	19a581b83ad1306fb0ef7d5e9d071b31e8506809
schema:url	https://doi.org/10.1101/2020.05.14.20100834
resource representing a document's title	COVID-19 management in a UK NHS Foundation Trust with a High Consequence Infectious Diseases centre: a detailed descriptive analysis
resource representing a document's body	covid:19a581b83ad1306fb0ef7d5e9d071b31e8506809#body_text
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