About: Growth hormone does not affect albumin synthesis in the critically ill

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Growth hormone does not affect albumin synthesis in the critically ill
Creator	Barle, H Barle, Hans Essøn, Pia Essønj, Gamrin, Lena Gamrin´p, ´l Garlick, Garlick, Peter Mcnurlan, Margaret Mcnurlan´p, M Wernerman, Jan Wernerman,
Source	PMC
abstract	Objective: To study the effect of growth hormone (GH) on albumin synthesis in critically ill patients. Design: Prospective randomized controlled study. Setting: Two intensive care units, university hospital and county hospital, respectively. Patients: Twenty-two critically ill patients in the intensive care unit. Interventions: Albumin synthesis was measured twice in each patient, with a 5-day interval. The patients in the control group (n=11) received standard intensive care unit (ICU) treatment between measurements, whereas those in the GH group (n=11) also received 0.3 U/kg daily of human recombinant GH. Measurements and results: Albumin synthesis was measured by labeling with L-[(2)H(5)]phenylalanine. In the control group, the fractional synthesis rate (FSR) of albumin was 16.3±4.1%/day (mean and SD) in the first measurement and 15.7±4.2%/day 5 days later (NS), whereas in the GH group the corresponding values were 17.0±4.7%/day and 16.7±5.5%/day (NS). The calculated absolute synthesis rates of albumin, based on FSR and intravascular albumin mass, also showed no effect of GH. Conclusion: Albumin synthesis rates were consistently higher in the two groups of critically ill patients than previously reported values in healthy subjects. However, GH treatment for 5 days neither stimulated nor inhibited albumin synthesis rates in these critically ill patients.
has issue date	2001-04-12(xsd:dateTime)
bibo:doi	10.1007/s001340100914
bibo:pmid	11430539
has license	no-cc
sha1sum (hex)	19bb9ba61969ea1e5dbcae13382cecb845064a9e
schema:url	https://doi.org/10.1007/s001340100914
resource representing a document's title	Growth hormone does not affect albumin synthesis in the critically ill
has PubMed Central identifier	PMC7095101
has PubMed identifier	11430539
schema:publication	Intensive Care Med
resource representing a document's body	covid:19bb9ba61969ea1e5dbcae13382cecb845064a9e#body_text
is schema:about of	named entity 'gluconeogenesis' named entity 'patients' named entity 'Critical' named entity 'studies' named entity 'albumin' named entity 'substrate' named entity 'Growth hormone' named entity 'blood chemistry' named entity 'critically ill patients' named entity 'Karolinska Institute' named entity 'albumin' named entity 'protein' named entity 'ICU' named entity 'critical illness' named entity 'plasma albumin' named entity 'catabolism' named entity 'substrate' named entity 'chronic health' named entity 'electron ionization' named entity 'Fisons' named entity 'skeletal muscle' named entity 'thrombosis' named entity 'isotopic enrichment' named entity 'amino acid' named entity 'albumin' named entity 'Hemel Hempstead' named entity 'amino acid' named entity 'intensive care units' named entity 'liver protein synthesis' named entity 'protein metabolism' named entity 'control group' named entity 'plasma' named entity 'correlation' named entity 'albumin' named entity 'ethanol' named entity 'plasma volume' named entity 'albumin' named entity 'amino acids' named entity 'critically ill patients' named entity 'phenylalanine' named entity 'insulin' named entity 'phenylalanine' named entity 'diuretics' named entity 'albumin' named entity 'insulin' named entity 'secretion' named entity 'liver protein synthesis' named entity 'phenylalanine' named entity 'plasma albumin' named entity 'secretion' named entity 'Albumin' named entity 'critically ill' named entity 'control group' named entity 'acute-phase response' named entity 'intensive care unit' named entity 'matrix-assisted laser desorption' named entity 'Phenylalanine' named entity 'Zoetermeer' named entity 'atom' named entity 'precipitate' named entity 'liver proteins' named entity 'protein synthesis' named entity 'plasma albumin' named entity 'critically ill' named entity 'secretion' named entity 'sedation' named entity 'hydrolyzed' named entity 'critically ill' named entity 'morbidity' named entity 'albumin'

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