About: Suicide Gene Therapy in Liver Tumors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Suicide Gene Therapy in Liver Tumors
Creator	Habib, Nagy Havlik, Roman Jensen, Steen Jiao, Long Nicholls, Joanna
source	PMC
abstract	Charaterization of a variety of genomic defects in malignant cells (1) has led to attempts to treat cancer by gene therapy. Gene therapy is a therapeutic approach in which therapeutic nucleic acids are transferred into the affected organs. Although the ideal concept would be the replacement of the abnormal gene by a copy of the functional gene, currently there have not been reliable and safe techniques to allow the site-specific integration of DNA into the human genome (2). Thus, almost all gene therapies are developed by simply transferring the therapeutic gene into somatic cells without replacing the abnormal gene. The goal is to identify and correct genetic abnormalities interfering with the cell cycle and to correct them in all cells. Technically, there are two methods amenable for gene transfer: reintroduction of in vitro transferred gene into the body and direct transfer of gene into the target cells in vivo.
has issue date	2004-01-01(xsd:dateTime)
bibo:doi	10.1385/1-59259-429-8:433
bibo:pmid	14657577
has license	no-cc
sha1sum (hex)	19bee00eeb37e92f9b770999c6263263bcd1d280
schema:url	https://doi.org/10.1385/1-59259-429-8:433
resource representing a document's title	Suicide Gene Therapy in Liver Tumors
has PubMed Central identifier	PMC7122362
has PubMed identifier	14657577
schema:publication	Suicide Gene Therapy
resource representing a document's body	covid:19bee00eeb37e92f9b770999c6263263bcd1d280#body_text
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