About: Passive immunity to porcine epidemic diarrhea virus following immunization of pregnant gilts with a recombinant orf virus vector expressing the spike protein

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About: Passive immunity to porcine epidemic diarrhea virus following immunization of pregnant gilts with a recombinant orf virus vector expressing the spike protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Passive immunity to porcine epidemic diarrhea virus following immunization of pregnant gilts with a recombinant orf virus vector expressing the spike protein
Creator	Nelson, Eric Dee, Scott Hain, Kyle Okda, Faten Diel, Diego Joshi, Lok Bauermann, V Faccin, Tatiane Fernandes, Maureen Fernando, · Maggioli, Mayara Singrey, ·
source	Medline; PMC
abstract	Passive immunity is critical for protection of neonatal piglets against porcine epidemic diarrhea virus (PEDV). Here, we investigated the immunogenicity of an orf virus (ORFV) vector expressing the full-length spike (S) protein of PEDV (ORFV-PEDV-S) in pregnant gilts and its ability to confer passive immunity and protection in piglets. Three doses of ORFV-PEDV-S were given to two groups of PEDV-negative pregnant gilts, with the last dose being administered two weeks prior to farrowing. One of the two groups immunized with the ORFV-PEDV-S recombinant virus was also exposed to live PEDV orally on day 31 post-immunization (pi). Antibody responses were assessed in serum, colostrum and milk of immunized gilts, and passive transfer of antibodies was evaluated in piglet sera. The protective efficacy of ORFV-PEDV-S was evaluated after challenge of the piglets with PEDV. PEDV-specific IgG, IgA and neutralizing antibody (NA) responses were detected in ORFV-PEDV-S-immunized and ORFV-PEDV-S-immunized/PEDV-exposed gilts. PEDV NA, IgG and IgA were detected in the serum of piglets born to immunized gilts, demonstrating the transfer of antibodies through colostrum and milk. Piglets born to immunized gilts showed reduced morbidity and a marked reduction in mortality after PEDV challenge in comparison to control piglets. Piglets born to gilts that received ORFV-PEDV-S and were exposed to live PEDV showed stronger NA responses and lower clinical scores when compared to piglets born to gilts immunized with ORFV-PEDV-S alone. These results demonstrate the potential of ORFV as a vaccine delivery platform capable of eliciting passive immunity against PEDV.
has issue date	2018-05-03(xsd:dateTime)
bibo:doi	10.1007/s00705-018-3855-1
bibo:pmid	29725899
has license	no-cc
sha1sum (hex)	19f55b3421782d278b0dd53f586f5fb1860fd122
schema:url	https://doi.org/10.1007/s00705-018-3855-1
resource representing a document's title	Passive immunity to porcine epidemic diarrhea virus following immunization of pregnant gilts with a recombinant orf virus vector expressing the spike protein
has PubMed Central identifier	PMC7086649
has PubMed identifier	29725899
schema:publication	Arch Virol
resource representing a document's body	covid:19f55b3421782d278b0dd53f586f5fb1860fd122#body_text
is schema:about of	named entity 'milk' named entity 'doses' named entity 'gilts' named entity 'PREGNANT' named entity 'MARKED' named entity 'RESPONSES' named entity 'ONE OF' named entity 'IMMUNIZED' named entity 'GROUPS' named entity 'PIGLET' named entity 'PROTEIN ' named entity 'IGG' named entity 'SCORES' named entity 'ELICITING' named entity 'MORBIDITY' named entity 'EXPOSED TO' named entity 'CLINICAL' named entity 'CHALLENGE' named entity 'TO CONTROL' named entity 'GIVEN' named entity 'ORALLY' named entity 'POTENTIAL' named entity 'RECOMBINANT VIRUS' named entity 'ITS' named entity 'SPECIFIC' named entity 'DETECTED' named entity 'CRITICAL' named entity 'IMMUNOGENICITY' named entity 'VACCINE DELIVERY' named entity 'REDUCED' named entity 'ADMINISTERED' named entity 'LENGTH' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'PASSIVE IMMUNITY' named entity 'EVALUATED' named entity 'PASSIVE IMMUNITY' named entity 'VECTOR' named entity 'RECOMBINANT' named entity 'VIRUS VECTOR' named entity 'ANTIBODIES' named entity 'BORN' named entity 'INVESTIGATED' named entity 'NEUTRALIZING ANTIBODY' named entity 'DOSE' named entity 'BEING' named entity 'ORF VIRUS' named entity 'TWO WEEKS' named entity 'COLOSTRUM' named entity 'SPIKE PROTEIN' named entity 'FOLLOWING' named entity 'IMMUNIZATION' named entity 'SERUM' named entity 'ASSESSED' named entity 'RESULTS' named entity 'SERA' named entity 'NEGATIVE' named entity 'PASSIVE' named entity 'EXPOSED' named entity 'LOWER' named entity 'THESE' named entity 'RECEIVED' named entity 'EFFICACY' named entity 'TRANSFER' named entity 'LIVE' named entity 'PLATFORM' named entity 'SPIKE' named entity 'MORTALITY' named entity 'MILK' named entity 'IGA' named entity 'COMPARISON'

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