About: Interferon gamma inhibits transmissible gastroenteritis virus infection mediated by an IRF1 signaling pathway

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About: Interferon gamma inhibits transmissible gastroenteritis virus infection mediated by an IRF1 signaling pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon gamma inhibits transmissible gastroenteritis virus infection mediated by an IRF1 signaling pathway
Creator	Shan, Lingling Liang, · Liu, · Fang Fu, · Feng, · Xue, · Zhu, ·
Source	Medline; PMC
abstract	Interferon gamma (IFN-γ) is best known for its ability to regulate host immune responses; however, its direct antiviral activity is less well studied. Transmissible gastroenteritis virus (TGEV) is an economically important swine enteric coronavirus and causes acute diarrhea in piglets. At present, little is known about the function of IFN-γ in the control of TGEV infection. In this study, we demonstrated that IFN-γ inhibited TGEV infection directly in ST cells and intestine epithelial IPEC-J2 cells and that the anti-TGEV activity of IFN-γ was independent of IFN-α/β. Moreover, IFN-γ suppressed TGEV infection in ST cells more efficiently than did IFN-α, and the combination of IFN-γ and IFN-α displayed a synergistic effect against TGEV. Mechanistically, using overexpression and functional knockdown experiments, we demonstrated that porcine interferon regulatory factor 1 (poIRF1) elicited by IFN-γ primarily mediated IFN-γ signaling cascades and the inhibition of TGEV infection by IFN-γ. Importantly, we found that TGEV elevated the expression of poIRF1 and IFN-γ in infected small intestines and peripheral blood mononuclear cells. Thus, IFN-γ plays a crucial role in curtailing enteric coronavirus infection and may serve as an effective prophylactic and/or therapeutic agent against TGEV infection.
has issue date	2019-08-05(xsd:dateTime)
bibo:doi	10.1007/s00705-019-04362-2
bibo:pmid	31385116
has license	no-cc
sha1sum (hex)	1a22c841a95f784a81243b8ce488d79212a62338
schema:url	https://doi.org/10.1007/s00705-019-04362-2
resource representing a document's title	Interferon gamma inhibits transmissible gastroenteritis virus infection mediated by an IRF1 signaling pathway
has PubMed Central identifier	PMC7086799
has PubMed identifier	31385116
schema:publication	Arch Virol
resource representing a document's body	covid:1a22c841a95f784a81243b8ce488d79212a62338#body_text
is schema:about of	named entity 'IRF1' named entity 'combination' named entity 'infection' named entity 'small intestines' named entity 'infection' named entity 'SWINE ENTERIC CORONAVIRUS' named entity 'ROLE' named entity 'TO REGULATE' named entity 'IMMUNE RESPONSES' named entity 'DID' named entity 'FUNCTIONAL' named entity 'PRESENT' named entity 'INDEPENDENT OF' named entity 'DIRECT' named entity 'KNOWN' named entity 'CORONAVIRUS INFECTION' named entity 'SIGNALING CASCADES' named entity 'ACTIVITY' named entity 'HOST' named entity 'CAUSES' named entity 'ECONOMICALLY IMPORTANT' covid:arg/1a22c841a95f784a81243b8ce488d79212a62338 named entity 'MEDIATED' named entity 'SYNERGISTIC' named entity 'VIRUS INFECTION' named entity 'IFN' named entity 'PLAYS' named entity 'CONTROL' named entity 'INTERFERON GAMMA ' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'INFECTION' named entity 'ENTERIC CORONAVIRUS' named entity 'CELLS' named entity 'EXPERIMENTS' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'ELEVATED' named entity 'SIGNALING PATHWAY' named entity 'INFECTED' named entity 'INTESTINE' named entity 'INTERFERON REGULATORY FACTOR 1' named entity 'BEST' named entity 'COMBINATION' named entity 'INTERFERON GAMMA ' named entity 'ABOUT' named entity 'INHIBITION' named entity 'EPITHELIAL' named entity 'ANTIVIRAL ACTIVITY' named entity 'ELICITED BY' named entity 'SMALL INTESTINES' named entity 'ITS' named entity 'FUNCTION' named entity 'SERVE' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'DISPLAYED' named entity 'MEDIATED' named entity 'SUPPRESSED' named entity 'OVEREXPRESSION' named entity 'INHIBITED' named entity 'EFFECT' named entity 'USING' named entity 'LITTLE' named entity 'PORCINE' named entity 'PROPHYLACTIC' named entity 'ACUTE DIARRHEA' named entity 'STUDY' named entity 'THERAPEUTIC AGENT' named entity 'EXPRESSION' named entity 'DEMONSTRATED' named entity 'EFFECTIVE' named entity 'efficiently' named entity 'IFN-γ' named entity 'infection' named entity 'inhibited' named entity 'economically' named entity 'IFN-γ'

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