About: Bovine coronaviruses associated with enteric and respiratory diseases in Canadian dairy cattle display different reactivities to anti-HE monoclonal antibodies and distinct amino acid changes in their HE, S and ns4.9 protein

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About: Bovine coronaviruses associated with enteric and respiratory diseases in Canadian dairy cattle display different reactivities to anti-HE monoclonal antibodies and distinct amino acid changes in their HE, S and ns4.9 protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bovine coronaviruses associated with enteric and respiratory diseases in Canadian dairy cattle display different reactivities to anti-HE monoclonal antibodies and distinct amino acid changes in their HE, S and ns4.9 protein
Creator	Boutin, Martine Gélinas, Anne-Marie Dea, Marie-Josée, A Sasseville, Serge
Source	Elsevier; Medline; PMC
abstract	Abstract Bovine coronavirus isolates associated with recent outbreaks of respiratory disease in Ontario and Quebec dairy farms were compared to reference strains known to be responsible for neonatal calf diarrhea (NCD) or winter dysentery (WD) of adult cattle. In respect to their hemagglutinating properties and their higher RDE activities with rat erythrocytes, WDBCoV strains differed from NCDBCoV strains and respiratory bovine coronaviruses RBCoV strains. Serologically, three MAbs directed to the HE glycoprotein of the WDBCoV strain BCQ.2590 recognized two serogroups amongst NCDBCoV strains by hemagglutination inhibition, whereas only one of the MAbs failed to react toward three of the four RBCoV isolates tested. Sequencing analysis of the S (S1 portion), HE, ORF4 and ORF5 genes of BCoV isolates associated with different clinical syndromes indicated that neither insertions or deletions could explain their distinct tropism. For the HE glycoprotein, a total of 15 amino acids (aa) substitutions were identified by comparing field isolates to the prototype Mebus strain. Two specific proline substitutions were identified for virulent strains being located in the signal peptides (aa 5) and aa position 367; one specific aa change was revealed at position 66 for RBCoV field isolates. Analysis of the S1 portion of the S glycoprotein revealed a total of eight aa changes specific to enteropathogenic (EBCoV) strains and eight aa changes specific to RBCoV strains. For all BCoV isolates studied, the region located between the S and M genes (ORF4) apparently encodes for two non-structural (ns) proteins of 4.9 and 4.8 kDa. A specific non-sense mutation was identified for the nucleotide at position 88 of the putative 4.9 kDa protein gene of RBCoV isolates resulting in 29 rather that 43 aa residues. The ORF5, which encodes a 12.7 ns protein and the 9.5 kDa E protein, was highly conserved amongst the BCoV field isolates.
has issue date	2001-07-01(xsd:dateTime)
bibo:doi	10.1016/s0168-1702(01)00243-x
bibo:pmid	11376845
has license	els-covid
sha1sum (hex)	1a52404c7cdc68445f80cb3ddde5781d4ec5cbe5
schema:url	https://doi.org/10.1016/s0168-1702%2801%2900243-x
resource representing a document's title	Bovine coronaviruses associated with enteric and respiratory diseases in Canadian dairy cattle display different reactivities to anti-HE monoclonal antibodies and distinct amino acid changes in their HE, S and ns4.9 protein
has PubMed Central identifier	PMC7127236
has PubMed identifier	11376845
schema:publication	Virus Research
resource representing a document's body	covid:1a52404c7cdc68445f80cb3ddde5781d4ec5cbe5#body_text
is schema:about of	named entity 'CORONAVIRUSES' named entity 'glycoprotein' named entity 'position' named entity 'virulent' named entity 'nucleotide' named entity 'diarrhea' named entity 'protein' named entity 'specific' named entity 'Ontario' named entity 'failed' named entity 'dairy cattle' named entity 'enteric' named entity 'DISPLAY' named entity 'CHANGES' covid:arg/1a52404c7cdc68445f80cb3ddde5781d4ec5cbe5 named entity 'SEROGROUPS' named entity 'BEING' named entity 'THEIR' named entity 'DIFFERENT' named entity 'POSITION' named entity 'DAIRY' named entity 'STRAIN' named entity 'PORTION' named entity 'IDENTIFIED BY' named entity 'KNOWN' named entity 'CATTLE' named entity 'PROTEIN ' named entity 'ORF5' named entity 'BOVINE CORONAVIRUS' named entity 'WINTER' named entity 'STRAINS' named entity 'FARMS' named entity 'COMPARED' named entity 'RDE' named entity 'RESULTING IN' named entity 'PROTEIN GENE' named entity 'MUTATION' named entity 'HIGHER' named entity 'NS4' named entity 'ANALYSIS' named entity 'ERYTHROCYTES' named entity 'DIRECTED' named entity 'NEITHER' named entity 'RECENT' named entity 'ONTARIO' named entity 'GENES' named entity 'OUTBREAKS' named entity 'PROPERTIES' named entity 'REVEALED' named entity 'APPARENTLY' named entity 'ACTIVITIES' named entity 'INSERTIONS' named entity 'RESPONSIBLE' named entity '12.7' named entity 'RESPIRATORY DISEASES' named entity 'BOVINE' named entity 'PROTEIN ' named entity 'TROPISM' named entity 'HEMAGGLUTINATION INHIBITION' named entity '9.5' named entity 'LOCATED IN' named entity 'CANADIAN' named entity 'ENTERIC' named entity 'AMINO ACID' named entity 'DISTINCT' named entity 'MONOCLONAL ANTIBODIES' named entity 'ASSOCIATED WITH' named entity 'ENTEROPATHOGENIC' named entity 'E PROTEIN' named entity 'GLYCOPROTEIN' named entity 'SPECIFIC' named entity 'SEQUENCING ANALYSIS' named entity 'KDA' named entity 'DIFFERENT' named entity 'DAIRY CATTLE' named entity 'RAT' named entity 'TOTAL'

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