About: Interferon Lambda: Opportunities, Risks, and Uncertainties in the Fight Against HCV

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interferon Lambda: Opportunities, Risks, and Uncertainties in the Fight Against HCV
Creator	Schönbach, Christian Dustin, Lynn Kazakhstan, Laidlaw, Stephen University, Nazarbayev
source	PMC
abstract	Innate immunity is key to the fight against the daily onslaught from viruses that our bodies are subjected to. Essential to this response are the interferons (IFNs) that prime our cells to block viral pathogens. Recent evidence suggests that the Type III (λ) IFNs are intimately associated with the immune response to hepatitis C virus (HCV) infection. Genome-wide association studies have identified polymorphisms within the IFN-λ gene locus that correlate with response to IFNα-based antiviral therapy and with spontaneous clearance of HCV infection. The mechanisms for these correlations are incompletely understood. Restricted expression of the IFN-λ receptor, and the ability of IFN-λ to induce IFN-stimulated genes in HCV-infected cells, suggest potential roles for IFN-λ in HCV therapy even in this era of directly acting antivirals. This review summarizes our current understanding of the IFN-λ family and the role of λ IFNs in the natural history of HCV infection.
has issue date	2014-10-31(xsd:dateTime)
bibo:doi	10.3389/fimmu.2014.00545
bibo:pmid	25400636
has license	cc-by
sha1sum (hex)	1a756a496c38e35c6d0a26df3a2eef4fb25c8aa8
schema:url	https://doi.org/10.3389/fimmu.2014.00545
resource representing a document's title	Interferon Lambda: Opportunities, Risks, and Uncertainties in the Fight Against HCV
has PubMed Central identifier	PMC4215632
has PubMed identifier	25400636
schema:publication	Front Immunol
resource representing a document's body	covid:1a756a496c38e35c6d0a26df3a2eef4fb25c8aa8#body_text
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