About: Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells

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About: Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells
Creator	Hewlett, Indira Zhao, Jiangqin Biswas, Santanu Wang, Xue Ye, Zhiping Devadas, Krishnakumar Tan, Jiying
Source	PMC
abstract	Influenza virus infection has a significant impact on public health, since it is a major cause of morbidity and mortality. It is not well-known whether influenza virus infection affects cell death and human immunodeficiency virus (HIV)-1 replication in HIV-1-infected patients. Using a lymphoma cell line, Jurkat, we examined the in vitro effects of pandemic influenza A (H1N1) virus (pH1N1) infection on cell death and HIV-1 RNA production in infected cells. We found that pH1N1 infection increased apoptotic cell death through Fas and Bax-mediated pathways in HIV-1-infected Jurkat cells. Infection with pH1N1 virus could promote HIV-1 RNA production by activating host transcription factors including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ĸB), nuclear factor of activated T-cells (NFAT) and activator protein 1 (AP-1) through mitogen-activated protein kinases (MAPK) pathways and T-cell antigen receptor (TCR)-related pathways. The replication of HIV-1 latent infection could be reactivated by pH1N1 infection through TCR and apoptotic pathways. These data indicate that HIV-1 replication can be activated by pH1N1 virus in HIV-1-infected cells resulting in induction of cell death through apoptotic pathways.
has issue date	2016-02-02(xsd:dateTime)
bibo:doi	10.3390/v8020033
bibo:pmid	26848681
has license	cc-by
sha1sum (hex)	1adab26eb1167a39014dc503174f7d34f9087664
schema:url	https://doi.org/10.3390/v8020033
resource representing a document's title	Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells
has PubMed Central identifier	PMC4776188
has PubMed identifier	26848681
schema:publication	Viruses
resource representing a document's body	covid:1adab26eb1167a39014dc503174f7d34f9087664#body_text
is schema:about of	named entity 'VIRUS INFECTION' named entity 'virus' named entity 'protein' named entity 'public health' named entity 'cell death' named entity 'INFECTED' named entity 'HIV-1 REPLICATION' covid:arg/1adab26eb1167a39014dc503174f7d34f9087664 named entity 'MITOGEN-ACTIVATED PROTEIN KINASES' named entity 'ACTIVATING' named entity 'HIV-1' named entity 'REACTIVATED' named entity 'IMPACT' named entity 'APOPTOTIC CELL DEATH' named entity 'HIV-1 RNA' named entity 'ACTIVATOR PROTEIN 1' named entity 'RELATED' named entity 'NOT WELL' named entity 'PROMOTE' named entity 'DATA' named entity 'T-CELL ANTIGEN RECEPTOR' named entity 'ACTIVATED' named entity 'JURKAT CELLS' named entity 'INFECTED' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'VIRUS INFECTION' named entity 'IS A' named entity 'JURKAT' named entity 'HOST' named entity 'EXAMINED' named entity 'CELL DEATH' named entity 'FAS' named entity 'INDUCTION' named entity 'BAX' named entity 'COULD BE' named entity 'TRANSCRIPTION FACTORS' named entity 'NUCLEAR FACTOR OF ACTIVATED T-CELLS' named entity 'INFLUENZA VIRUS' named entity 'INCLUDING' named entity 'NUCLEAR FACTOR KAPPA-LIGHT-CHAIN-ENHANCER OF ACTIVATED B CELLS' named entity 'USING' named entity 'EFFECTS' named entity 'KNOWN' named entity 'JURKAT CELLS' named entity 'APOPTOSIS' named entity 'PANDEMIC' named entity 'INCREASES' named entity 'TCR' named entity 'SIGNIFICANT' named entity 'A MAJOR' named entity 'REPLICATION' named entity 'MEDIATED' named entity 'APOPTOTIC' named entity 'HIV-1' named entity 'VIRUS' named entity 'LATENT INFECTION' named entity 'INFLUENZA A' named entity 'CELLS' named entity 'INFLUENZA A' named entity 'PATHWAYS' named entity 'INFECTION' named entity 'THESE' named entity 'PATIENTS' named entity 'PANDEMIC' named entity 'IN VITRO' named entity 'INCREASED' named entity 'RESULTING IN' named entity 'PRODUCTION' named entity 'CAUSE' named entity 'MORBIDITY AND MORTALITY' named entity 'PUBLIC HEALTH' named entity 'ON CELL' named entity 'HIV-1 REPLICATION' named entity 'LYMPHOMA CELL LINE' named entity 'FOUND'

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