About: Evidence for electrogenic sodium-dependent ascorbate transport in rat astroglia

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About: Evidence for electrogenic sodium-dependent ascorbate transport in rat astroglia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evidence for electrogenic sodium-dependent ascorbate transport in rat astroglia
Creator	Dixon, S Jaworski, Ewa Wilson, John
Source	PMC
abstract	The dependence of ascorbate uptake on external cations was studied in primary cultures of rat cerebral astrocytes. Initial rates of ascorbate uptake were diminished by lowering the external concentrations of either Ca(2+) or Na(+). The Na(+)-dependence of astroglial ascorbate uptake gave Hill coefficients of approximately 2, consistent with a Na(+)-ascorbate cotransport system having stoichiometry of 2 Na(+)∶1 ascorbate anion. Raising external K(+) concentration incrementally from 5.4 to 100 mM, so as to depolarize the plasma membrane, decreased the initial rate of ascorbate uptake, with the degree of inhibition depending on the level of K(+). The depolarizing ionophores gramicidin and nystatin slowed ascorbate uptake by astrocytes incubated in 5.4 mM K(+); whereas, the nondepolarizing ionophore valinomycin did not. Qualitatively similar results were obtained whether or not astrocytes were pretreated with dibutyryl cyclic AMP (0.25 mM for 2 weeks) to induce stellation. These data are consistent with the existence of an electrogenic Na(+)-ascorbate cotransport system through which the rate of ascorbate uptake is modulated by endogenous agents, such as K(+), that alter astroglial membrane potential.
has issue date	1991-01-01(xsd:dateTime)
bibo:doi	10.1007/bf00965831
bibo:pmid	1711164
has license	no-cc
sha1sum (hex)	1b00ea5ca68e6e9bf012326efb9a4d07da5515e8
schema:url	https://doi.org/10.1007/bf00965831
resource representing a document's title	Evidence for electrogenic sodium-dependent ascorbate transport in rat astroglia
has PubMed Central identifier	PMC7089219
has PubMed identifier	1711164
schema:publication	Neurochem Res
resource representing a document's body	covid:1b00ea5ca68e6e9bf012326efb9a4d07da5515e8#body_text
is schema:about of	named entity 'ASTROGLIA' named entity 'CONCENTRATION' named entity 'IONOPHORES' named entity 'DID' named entity 'SLOWED' named entity '4 MM' named entity 'DIBUTYRYL CYCLIC AMP' named entity 'RESULTS' named entity 'RAT' named entity 'PRIMARY CULTURES' named entity 'ANION' named entity 'studied' named entity 'cultures' named entity 'external' named entity 'SODIUM' named entity 'STOICHIOMETRY' named entity 'APPROXIMATELY' named entity 'SYSTEM' named entity 'ASTROCYTES' named entity 'RAT' named entity 'MODULATED' named entity 'DEGREE' named entity '2 WEEKS' named entity 'ASCORBATE' named entity 'CEREBRAL' named entity 'OBTAINED' named entity 'INITIAL' named entity 'EXTERNAL' named entity 'LOWERING' named entity 'PLASMA MEMBRANE' named entity 'TRANSPORT' named entity 'DECREASED' named entity 'GAVE' named entity 'ALTER' named entity 'RATES' named entity 'CATIONS' named entity '5.4' named entity 'INHIBITION' named entity 'EITHER' named entity 'CONCENTRATIONS' named entity 'RATE' named entity 'ENDOGENOUS' named entity '100' named entity 'NYSTATIN' named entity 'GRAMICIDIN' named entity 'CONSISTENT WITH' named entity 'SIMILAR' named entity 'INCUBATED' named entity 'ASCORBATE' named entity 'DEPENDENT' named entity 'EVIDENCE FOR' named entity 'DIMINISHED' named entity 'LEVEL' named entity 'DATA' named entity 'COEFFICIENTS' named entity 'IONOPHORE' named entity 'COTRANSPORT' named entity 'INDUCE' named entity 'VALINOMYCIN' named entity 'THESE' named entity 'DEPENDENCE' named entity 'HILL' named entity 'MEMBRANE POTENTIAL' named entity 'UPTAKE' covid:arg/1b00ea5ca68e6e9bf012326efb9a4d07da5515e8 named entity 'cotransport' named entity 'concentration' named entity 'astrocytes' named entity 'coefficients' named entity 'ionophore' named entity 'ionophores' named entity 'ascorbate' named entity 'ascorbate' named entity 'cyclic AMP' named entity 'ascorbate' named entity 'cations' named entity 'anion' named entity 'astroglial' named entity 'gramicidin'

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