About: Development and validation of an HILIC–MS/MS method by one-step precipitation for chloroquine in miniature pig plasma

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About: Development and validation of an HILIC–MS/MS method by one-step precipitation for chloroquine in miniature pig plasma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development and validation of an HILIC–MS/MS method by one-step precipitation for chloroquine in miniature pig plasma
Creator	Zhang, Ming Lu, Hao-Yang Ni, Xiao-Jia Shang, De-Wei Wang, Zhan-Zhang Wen, Yu-Guan
Source	PMC
abstract	BACKGROUND: Quantification of polar compounds such as chloroquine by revered-phase LC is a challenge because of poor retention and silanol interactions with stationary phase. Strong ion-pairing reagents added to mobile phases to improve reversed-phase retention and improve peak shape can be harmful for MS. RESULTS: This new approach provides a rapid and sensitive method for the detection of chloroquine using hydrophilic interaction LC coupled to MS/MS (HILIC–MS/MS). Ammonium formate and formic acid were added to mobile phase to attain good peak shapes and the salified chloroquine as well retained in an HILIC column. Linearity, intra- and inter-day precision, accuracy, recovery, matrix effect and stability were evaluated during the validation process. CONCLUSION: The validated method has been successfully used in a PK study in miniature pigs, and paves way for future development.
has issue date	2016-05-23(xsd:dateTime)
bibo:doi	10.4155/bio-2015-0032
bibo:pmid	27211608
has license	cc-by
sha1sum (hex)	1b0ca64f631b15f4763e6731aa9e2f84c7be751e
schema:url	https://doi.org/10.4155/bio-2015-0032
resource representing a document's title	Development and validation of an HILIC–MS/MS method by one-step precipitation for chloroquine in miniature pig plasma
has PubMed Central identifier	PMC7099630
has PubMed identifier	27211608
schema:publication	Bioanalysis
resource representing a document's body	covid:1b0ca64f631b15f4763e6731aa9e2f84c7be751e#body_text
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