About: A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus
Creator	Maestri, Alvino Domingues, Aline Gonzalez-Nieto, Lucas Nogueira, Juliana Trindade, Mateus Burton, Dennis Levi, José Whitehead, Stephen Kallas, Esper Nogueira, Mauricio Ricciardi, Michael Watkins, David Desrosiers, Ronald Avelino-Silva, Vivian Bailey, Varian Felix, Alvina Fuchs, Sebastian Gutman, Martin Martinez-Navio, José Martins, Mauricio Maxwell, Helen Nú, Ria Oliveira, Consuelo Pedreño-Lopez, Rosen, Brandon Silveira, Cassia
Source	PMC
abstract	The isolation of neutralizing monoclonal antibodies (nmAbs) against the Zika virus (ZIKV) might lead to novel preventative strategies for infections in at-risk individuals, primarily pregnant women. Here we describe the characterization of human mAbs from the plasmablasts of an acutely infected patient. One of the 18 mAbs had the unusual feature of binding to and neutralizing ZIKV despite not appearing to have been diversified by affinity maturation. This mAb neutralized ZIKV (Neut(50) ~ 2 μg/ml) but did not react with any of the four dengue virus serotypes. Except for the expected junctional diversity created by the joining of the V-(D)-J genes, there was no deviation from immunoglobulin germline genes. This is a rare example of a human mAb with neutralizing activity in the absence of detectable somatic hypermutation. Importantly, binding of this mAb to ZIKV was specifically inhibited by human plasma from ZIKV-exposed individuals, suggesting that it may be of value in a diagnostic setting.
has issue date	2017-06-12(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0005655
bibo:pmid	28604797
has license	cc0
sha1sum (hex)	1b41bb775aaf552e944aceaa31f52814e264c78d
schema:url	https://doi.org/10.1371/journal.pntd.0005655
resource representing a document's title	A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus
has PubMed Central identifier	PMC5481143
has PubMed identifier	28604797
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:1b41bb775aaf552e944aceaa31f52814e264c78d#body_text
is schema:about of	named entity 'ZIKA VIRUS' named entity 'plasma' named entity 'epitope' named entity 'HUMAN' named entity 'HAVE' named entity 'JOINING' named entity 'UNUSUAL' named entity 'SETTING' named entity 'MONOCLONAL ANTIBODIES' named entity 'CREATED BY' named entity 'GENES' named entity 'LEAD' named entity 'PREVENTATIVE' named entity 'RARE' named entity 'DESCRIBE' named entity 'EPITOPE' named entity 'GERMLINE' named entity 'VALUE' named entity 'EXPOSED' named entity 'JUNCTIONAL' named entity 'DEVIATION' named entity 'AFFINITY MATURATION' named entity 'CHARACTERIZATION' named entity 'FEATURE' named entity 'RISK' named entity 'STRATEGIES' named entity 'EXCEPT FOR' named entity 'PREGNANT WOMEN' named entity 'AT-' named entity 'ACTIVITY' named entity 'PATIENT' named entity 'IS A' named entity 'BCG' named entity 'GERMLINE' named entity 'DETECTABLE' named entity 'BINDING' named entity 'DIAGNOSTIC' named entity 'ONE OF' named entity 'ZIKA VIRUS' named entity 'BINDS' named entity 'INFECTIONS' named entity 'MAY BE' named entity 'INFERRED' named entity 'IMMUNOGLOBULIN' named entity 'DID' named entity 'ISOLATION' named entity 'BUT' named entity 'NOVEL' named entity 'HERE' named entity 'SOMATIC HYPERMUTATION' named entity 'DIVERSITY' named entity 'DENGUE VIRUS' named entity 'INFECTED' named entity 'HUMAN PLASMA' named entity 'INDIVIDUALS' named entity 'REACT'

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