About: Serological characterization of guinea pigs infected with H3N2 human influenza or immunized with hemagglutinin protein

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About: Serological characterization of guinea pigs infected with H3N2 human influenza or immunized with hemagglutinin protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serological characterization of guinea pigs infected with H3N2 human influenza or immunized with hemagglutinin protein
Creator	Schultz-Cherry, Stacey Long, Jinxue Bushnell, Ruth Chaudhuri, A Nara, Peter Tobin, Gregory Tobin, John
Source	Medline; PMC
abstract	BACKGROUND: Recent and previous studies have shown that guinea pigs can be infected with, and transmit, human influenza viruses. Therefore guinea pig may be a useful animal model for better understanding influenza infection and assessing vaccine strategies. To more fully characterize the model, antibody responses following either infection/re-infection with human influenza A/Wyoming/03/2003 H3N2 or immunization with its homologous recombinant hemagglutinin (HA) protein were studied. RESULTS: Serological samples were collected and tested for anti-HA immunoglobulin by ELISA, antiviral antibodies by hemagglutination inhibition (HI), and recognition of linear epitopes by peptide scanning (PepScan). Animals inoculated with infectious virus demonstrated pronounced viral replication and subsequent serological conversion. Animals either immunized with the homologous HA antigen or infected, showed a relatively rapid rise in antibody titers to the HA glycoprotein in ELISA assays. Antiviral antibodies, measured by HI assay, were detectable after the second inoculation. PepScan data identified both previously recognized and newly defined linear epitopes. CONCLUSIONS: Infection and/or recombinant HA immunization of guinea pigs with H3N2 Wyoming influenza virus resulted in a relatively rapid production of viral-specific antibody thus demonstrating the strong immunogenicity of the major viral structural proteins in this animal model for influenza infection. The sensitivity of the immune response supports the utility of the guinea pig as a useful animal model of influenza infection and immunization.
has issue date	2010-08-24(xsd:dateTime)
bibo:doi	10.1186/1743-422x-7-200
bibo:pmid	20735849
has license	cc-by
sha1sum (hex)	1b5d310d0656503b1d2fbc612625496a3266ae16
schema:url	https://doi.org/10.1186/1743-422x-7-200
resource representing a document's title	Serological characterization of guinea pigs infected with H3N2 human influenza or immunized with hemagglutinin protein
has PubMed Central identifier	PMC2939558
has PubMed identifier	20735849
schema:publication	Virol J
resource representing a document's body	covid:1b5d310d0656503b1d2fbc612625496a3266ae16#body_text
is schema:about of	named entity 'H3N2' named entity 'Serological' named entity 'samples' named entity 'immunization' named entity 'antibody' named entity 'hemagglutinin' named entity 'SEROLOGICAL' covid:arg/1b5d310d0656503b1d2fbc612625496a3266ae16 named entity 'GUINEA PIG' named entity 'ITS' named entity 'HEMAGGLUTININ' named entity 'STRATEGIES' named entity 'FULLY' named entity 'WYOMING' named entity 'DEMONSTRATED' named entity 'VIRUS' named entity 'ANTIBODIES' named entity 'IMMUNOGENICITY' named entity 'PEPTIDE' named entity 'VIRAL STRUCTURAL PROTEINS' named entity 'COLLECTED' named entity 'SAMPLES' named entity 'DEFINED' named entity 'ANTIBODY TITERS' named entity 'INFLUENZA VIRUS' named entity 'INFLUENZA A' named entity 'INFECTED' named entity 'UTILITY' named entity 'CONVERSION' named entity 'DETECTABLE' named entity 'VIRAL REPLICATION' named entity 'MODEL OF' named entity 'PROTEIN ' named entity 'MAJOR' named entity 'EPITOPES' named entity 'RESPONSES' named entity 'H3N2' named entity 'INFLUENZA VIRUSES' named entity 'INOCULATION' named entity 'IMMUNOGLOBULIN' named entity 'IMMUNIZATION' named entity 'CONCLUSIONS' named entity 'ANTIBODY' named entity 'STRONG' named entity 'INFLUENZA INFECTION' named entity 'RECOGNITION' named entity 'PREVIOUS' named entity 'LINEAR' named entity 'CHARACTERIZATION' named entity 'H3N2' named entity 'GUINEA PIGS' named entity 'EITHER' named entity 'PRODUCTION' named entity 'TESTED FOR' named entity 'GUINEA PIGS' named entity 'MEASURED' named entity 'HAVE' named entity 'ANIMALS' named entity 'ASSESSING' named entity 'HEMAGGLUTINATION INHIBITION' named entity 'ANIMAL MODEL' named entity 'ANTIVIRAL' named entity 'PROTEIN' named entity 'RECOMBINANT' named entity 'SCANNING' named entity 'HEMAGGLUTININ' named entity 'HUMAN INFLUENZA' named entity 'SENSITIVITY' named entity 'STUDIES' named entity 'SPECIFIC ANTIBODY' named entity 'SUBSEQUENT' named entity 'BETTER' named entity 'RAPID' named entity 'MODEL' named entity 'IMMUNIZED'

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