About: Severe lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors

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About: Severe lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Severe lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors
Creator	Mattiello, Rita Arruda, Eurico Cintra, Otávio Ribeiro, José Delcaro, Luana Jones, Marcus Sarria, Edgar Stein, Renato Escremim De Paula, Flávia Luis Proença-Modena, José Márcio Condessa Pitrez, Paulo Rodrigues Da Silva, Emerson
source	Medline; PMC
abstract	BACKGROUND: Lower respiratory tract infection (LRTI) is a major cause of pediatric morbidity and mortality, especially among non-affluent communities. In this study we determine the impact of respiratory viruses and how viral co-detections/infections can affect clinical LRTI severity in children in a hospital setting. METHODS: Patients younger than 3 years of age admitted to a tertiary hospital in Brazil during the months of high prevalence of respiratory viruses had samples collected from nasopharyngeal aspiration. These samples were tested for 13 different respiratory viruses through real-time PCR (rt-PCR). Patients were followed during hospitalization, and clinical data and population characteristics were collected during that period and at discharge to evaluate severity markers, especially length of hospital stay and oxygen use. Univariate regression analyses identified potential risk factors and multivariate logistic regressions were used to determine the impact of specific viral detections as well as viral co-detections in relation to clinical outcomes. RESULTS: We analyzed 260 episodes of LRTI with a viral detection rate of 85% (n = 222). Co-detection was observed in 65% of all virus-positive episodes. The most prevalent virus was Respiratory Syncytial Virus (RSV) (54%), followed by Human Metapneumovirus (hMPV) (32%) and Human Rhinovirus (HRV) (21%). In the multivariate models, infants with co-detection of HRV + RSV stayed 4.5 extra days (p = 0.004), when compared to infants without the co-detection. The same trends were observed for the outcome of days of supplemental oxygen use. CONCLUSIONS: Although RSV remains as the main cause of LRTI in infants our study indicates an increase in the length of hospital stay and oxygen use in infants with HRV detected by RT-PCR compared to those without HRV. Moreover, one can speculate that when HRV is detected simultaneously with RSV there is an additive effect that may be reflected in more severe clinical outcome. Also, our study identified a significant number of children infected by recently identified viruses, such as hMPV and Human Bocavirus (HBov), and this is a novel finding for poor communities from developing countries.
has issue date	2013-01-25(xsd:dateTime)
bibo:doi	10.1186/1471-2334-13-41
bibo:pmid	23351117
has license	cc-by
sha1sum (hex)	1b8bd44173742cd254617aabc5fdf20fb98f4072
schema:url	https://doi.org/10.1186/1471-2334-13-41
resource representing a document's title	Severe lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors
has PubMed Central identifier	PMC3598993
has PubMed identifier	23351117
schema:publication	BMC Infect Dis
resource representing a document's body	covid:1b8bd44173742cd254617aabc5fdf20fb98f4072#body_text
is schema:about of	named entity 'NON-' named entity 'RISK FACTORS' named entity 'viral' named entity 'pediatric' named entity 'viral' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'HOSPITAL' named entity 'COMMUNITIES' named entity 'CLINICAL' named entity 'IS A' named entity 'BACKGROUND' named entity 'RESPIRATORY VIRUSES' named entity 'DETERMINE' named entity 'IMPACT' named entity 'CHILDREN' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'NON-' named entity 'SEVERITY' named entity 'MORBIDITY AND MORTALITY' named entity 'LRTI' named entity 'AFFLUENT' named entity 'VIRAL' named entity 'AFFECT' named entity 'CAUSE' named entity 'DETECTION' named entity 'SEVERE' named entity 'INFANTS' named entity 'PEDIATRIC' named entity 'A MAJOR' named entity 'SETTING' named entity 'TODDLERS' named entity 'STUDY' named entity 'ETIOLOGY' named entity 'POPULATION' named entity 'HOW' named entity 'VIRAL' named entity 'AFFLUENT' covid:arg/1b8bd44173742cd254617aabc5fdf20fb98f4072 named entity 'viruses' named entity 'infants' named entity 'LRTI' named entity 'pediatric' named entity 'lower respiratory tract infection' named entity 'supplemental oxygen' named entity 'HRV' named entity 'tachypnea' named entity 'Viral Pathogenesis' named entity 'Supplemental oxygen' named entity 'SPSS' named entity 'primers' named entity '5.5' named entity 'public health' named entity 'viruses' named entity 'human coronavirus' named entity 'HRV' named entity 'supplemental oxygen' named entity 'clinical outcomes' named entity 'asthma' named entity 'infection' named entity 'bronchial epithelial cells' named entity 'Ethics' named entity 'Promega' named entity 'LRTI' named entity 'bacteria' named entity 'emergency room' named entity 'HRV' named entity 'HRV' named entity 'LRTI' named entity 'virus' named entity 'maternal smoking during pregnancy'

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