About: γδ T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection

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About: γδ T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	γδ T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection
Creator	Hu, Yu He, Wei Chen, Hui Ju, Xiangwu Yan, Yiwu Zhang, Jianmin Cai, Menghua Cui, Lianxian Dong, Peng Wang, Huaishan Zhang, Siya Chen, Wanjun Li, Xiao-Kang Zhuang, Yuan
Source	PMC
abstract	Given the high mortality rate (>50%) and potential danger of intrapersonal transmission, highly pathogenic avian influenza (HPAI) H5N1 epidemics still pose a significant threat to humans. γδ T cells, which participate on the front line of the host immune defense, demonstrate both innate, and adaptive characteristics in their immune response and have potent antiviral activity against various viruses. However, the roles of γδ T cells in HPAI H5N1 viral infection remain unclear. In this study, we found that γδ T cells provided a crucial protective function in the defense against HPAI H5N1 viral infection. HPAI H5N1 viruses could directly activate γδ T cells, leading to enhanced CD69 expression and IFN-γ secretion. Importantly, we found that the trimer but not the monomer of HPAI H5N1 virus hemagglutinin (HA) proteins could directly activate γδ T cells. HA-induced γδ T cell activation was dependent on both sialic acid receptors and HA glycosylation, and this activation could be inhibited by the phosphatase calcineurin inhibitor cyclosporin A but not by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002. Our findings provide a further understanding the mechanism underlying γδ T cell-mediated innate and adoptive immune responses against HPAI H5N1 viral infection, which helps to develop novel therapeutic strategies for the treatment of H5N1 infection in the future.
has issue date	2018-12-04(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.02812
bibo:pmid	30564234
has license	cc-by
sha1sum (hex)	1bd1b038d7ed985902aeef21bc1493eda76cdab5
schema:url	https://doi.org/10.3389/fimmu.2018.02812
resource representing a document's title	γδ T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection
has PubMed Central identifier	PMC6288289
has PubMed identifier	30564234
schema:publication	Front Immunol
resource representing a document's body	covid:1bd1b038d7ed985902aeef21bc1493eda76cdab5#body_text
is schema:about of	named entity 'HIGHLY' named entity 'activate' named entity 'phosphatidylinositol 3-kinase' named entity 'enhanced' named entity 'hemagglutinin' named entity 'receptors' named entity 'Virus' named entity 'AVIAN' named entity 'GIVEN' named entity 'UNCLEAR' named entity 'WORTMANNIN' named entity 'HEMAGGLUTININ' named entity 'DIRECTLY' named entity 'FINDINGS' named entity 'EPIDEMICS' named entity 'PATHOGENIC' named entity 'H5N1 INFLUENZA' named entity 'THREAT' named entity 'FUTURE' named entity 'LY294002' covid:arg/1bd1b038d7ed985902aeef21bc1493eda76cdab5 named entity 'IMMUNE' named entity 'LEADING' named entity 'MECHANISM' named entity 'HELPS' named entity 'SECRETION' named entity 'STUDY' named entity 'POTENTIAL' named entity 'HPAI' named entity 'HAVE' named entity 'ANTIVIRAL ACTIVITY' named entity 'INHIBITED' named entity 'GLYCOSYLATION' named entity 'DEFENSE' named entity 'UNDERSTANDING' named entity 'MONOMER' named entity 'INHIBITORS' named entity 'ROLES' named entity 'CYCLOSPORIN A' named entity 'EXPRESSION' named entity 'LINE' named entity 'INFLUENZA A VIRUS INFECTION' named entity 'FUNCTION' named entity 'PROVIDE' named entity 'DANGER' named entity 'IMMUNE RESPONSE' named entity 'INFECTION' named entity 'VARIOUS' named entity 'PROTEINS' named entity 'HPAI H5N1 VIRUS' named entity 'TRANSMISSION' named entity 'BUT' named entity 'H5N1' named entity 'INDUCED' named entity 'POSE' named entity 'TREATMENT' named entity 'SIGNIFICANT' named entity 'FOUND' named entity 'PHOSPHATIDYLINOSITOL 3-KINASE' named entity 'T CELL' named entity 'IFN' named entity 'TRIMER' named entity 'ACTIVATE' named entity 'DEPENDENT' named entity 'CALCINEURIN INHIBITOR' named entity 'PROVIDE' named entity 'PHOSPHATASE' named entity 'VIRAL INFECTION'

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