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About:
Early diagnosis of dengue disease severity in a resource-limited Asian country
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Early diagnosis of dengue disease severity in a resource-limited Asian country
Creator
Buchy, Philippe
Tarantola, Arnaud
Cavailler, Philippe
Rachline, Anne
Duong, Veasna
Duch, Moniboth
Huy, Rekol
Kdan, Yuvatha
Brett, Jeremy
Leo, Yee
Lover, Andrew
Quake, Ai
source
Medline; PMC
abstract
BACKGROUND: Dengue is endemic throughout Cambodia, a country faced with significant health and economic challenges. We undertook a clinical study at the National Paediatric Hospital in Phnom Penh to evaluate clinical diagnostic parameters for dengue and predictors of disease outcome. METHODS: Between September 2011 and January 2013, all consecutive inpatients aged between 1 and 15 years and presenting with suspected dengue were enrolled. They were clinically assessed using both the 1997 and 2009 WHO dengue classifications. Specimens were collected upon admission and discharge and tested for dengue at Institut Pasteur in Cambodia. RESULTS: A total of 701 patients were screened. Of these, 79 % were dengue-confirmed by laboratory testing, and 21 % tested dengue-negative. A positive tourniquet test, absence of upper respiratory symptoms, leukopenia, thrombocytopenia, and elevated liver transaminases were independent predictors for laboratory-confirmed dengue among the children. The presence of several warning signs on hospital admission was associated with a concurrent laboratory-confirmed diagnosis of severe disease outcome. CONCLUSIONS: The presence of two or more warning signs was associated with a concurrent laboratory-confirmed diagnosis of severe dengue at hospital admission. Thus, a cumulative score combining simple clinical parameters and first-line laboratory findings could be used to accurately predict dengue virus infection in pediatric populations, optimizing triage in settings with limited laboratory resources. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-016-1849-8) contains supplementary material, which is available to authorized users.
has issue date
2016-09-26
(
xsd:dateTime
)
bibo:doi
10.1186/s12879-016-1849-8
bibo:pmid
27670906
has license
cc-by
sha1sum (hex)
1bef85a33a74c3d1765752da0e715fc3a46e00d8
schema:url
https://doi.org/10.1186/s12879-016-1849-8
resource representing a document's title
Early diagnosis of dengue disease severity in a resource-limited Asian country
has PubMed Central identifier
PMC5036306
has PubMed identifier
27670906
schema:publication
BMC Infect Dis
resource representing a document's body
covid:1bef85a33a74c3d1765752da0e715fc3a46e00d8#body_text
is
schema:about
of
named entity 'Hospital'
named entity 'triage'
named entity 'dengue virus'
named entity 'inpatients'
named entity 'dengue'
named entity 'severe'
named entity 'LIMITED'
named entity 'DISEASE SEVERITY'
named entity 'EARLY DIAGNOSIS'
named entity 'HOSPITAL'
named entity 'PRESENTING'
named entity 'NATIONAL'
named entity 'CONCURRENT'
named entity 'TOTAL'
named entity 'DISCHARGE'
named entity 'INDEPENDENT PREDICTORS'
named entity 'CLASSIFICATIONS'
named entity 'ASSESSED'
named entity 'USING'
named entity 'SETTINGS'
named entity 'ABSENCE OF'
named entity 'FINDINGS'
named entity 'PASTEUR'
named entity 'CONSECUTIVE'
named entity 'ENROLLED'
named entity 'CHALLENGES'
named entity 'RESOURCE'
named entity 'LABORATORY RESOURCES'
named entity 'INPATIENTS'
named entity 'UPPER'
named entity 'LEUKOPENIA'
named entity 'TESTED'
named entity 'HOSPITAL ADMISSION'
named entity 'CONFIRMED BY'
named entity 'LABORATORY TESTING'
named entity 'PRESENCE OF'
named entity 'DISEASE OUTCOME'
named entity 'DENGUE'
named entity 'YEARS'
named entity 'COLLECTED'
named entity '2011'
named entity 'CUMULATIVE'
named entity 'CONFIRMED DIAGNOSIS'
named entity 'ENDEMIC'
named entity 'CONFIRMED'
named entity 'JANUARY'
named entity 'POPULATIONS'
named entity 'TESTED FOR'
named entity 'SPECIMENS'
named entity 'ECONOMIC'
named entity 'PARAMETERS'
named entity 'SEVERE DENGUE'
named entity 'EVALUATE'
named entity 'WARNING SIGNS'
named entity 'SEVERE DISEASE'
named entity 'SIGNIFICANT'
named entity '1997'
named entity 'LIMITED'
named entity 'POSITIVE'
named entity 'BACKGROUND'
named entity 'CHILDREN'
named entity 'TOURNIQUET TEST'
named entity 'COULD BE'
named entity 'CAMBODIA'
named entity 'TRIAGE'
named entity 'LINE'
named entity 'COMBINING'
named entity 'LABORATORY'
named entity 'SUSPECTED DENGUE'
named entity 'NEGATIVE'
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