About: Comparative genomic analysis of the swine pathogen Bordetella bronchisepticastrain KM22

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About: Comparative genomic analysis of the swine pathogen Bordetella bronchisepticastrain KM22 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comparative genomic analysis of the swine pathogen Bordetella bronchisepticastrain KM22
Creator	Bayles, Darrell Kingsley, Robert Nicholson, Tracy Register, Karen Shore, Sarah Brunelle, Brian
topic	covid:1bf6de18aec2c9d092d17543fba178914aca2cfa#this
source	Elsevier; Medline; PMC
abstract	The well-characterized Bordetella bronchiseptica strain KM22, originally isolated from a pig with atrophic rhinitis, has been used to develop a reproducible swine respiratory disease model. The goal of this study was to identify genetic features unique to KM22 by comparing the genome sequence of KM22 to the laboratory reference strain RB50. To gain a broader perspective of the genetic relationship of KM22 among other B. bronchiseptica strains, selected genes of KM22 were then compared to five other B. bronchiseptica strains isolated from different hosts. Overall, the KM22 genome sequence is more similar to the genome sequences of the strains isolated from animals than the strains isolated from humans. The majority of virulence gene expression in Bordetella is positively regulated by the two-component sensory transduction system BvgAS. bopN, bvgA, fimB, and fimC were the most highly conserved BvgAS-regulated genes present in all seven strains analyzed. In contrast, the BvgAS-regulated genes present in all seven strains with the highest sequence divergence werefimN, fim2, fhaL, andfhaS. A total of eight major fimbrial subunit genes were identified in KM22. Quantitative real-time PCR data demonstrated that seven of the eight fimbrial subunit genes identified in KM22 are expressed and regulated by BvgAS. The annotation of the KM22 genome sequence, coupled with the comparative genomic analyses reported in this study, can be used to facilitate the development of vaccines with improved efficacy towards B. bronchiseptica in swine to decrease the prevalence and disease burden caused by this pathogen.
has issue date	2016-01-15(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2015.10.026
bibo:pmid	26711033
has license	no-cc
sha1sum (hex)	1bf6de18aec2c9d092d17543fba178914aca2cfa
schema:url	https://doi.org/10.1016/j.vetmic.2015.10.026
resource representing a document's title	Comparative genomic analysis of the swine pathogen Bordetella bronchisepticastrain KM22
has PubMed Central identifier	PMC7117204
has PubMed identifier	26711033
schema:publication	Vet Microbiol
resource representing a document's body	covid:1bf6de18aec2c9d092d17543fba178914aca2cfa#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/1bf6de18aec2c9d092d17543fba178914aca2cfa
is schema:about of	named entity 'COMPARATIVE GENOMIC ANALYSIS' named entity 'strains' named entity 'reproducible' named entity 'strain' named entity 'regulated' named entity 'BORDETELLA BRONCHISEPTICA' named entity 'FEATURES' named entity 'BURDEN' named entity 'CONSERVED' named entity 'SELECTED' named entity 'PIG' named entity 'FIM2' named entity 'SWINE' named entity 'COMPARING' named entity 'DIFFERENT' named entity 'GOAL' named entity 'ANALYZED' named entity 'GENETIC' named entity 'SEQUENCES' named entity 'HOSTS' named entity 'ATROPHIC RHINITIS' named entity 'MAJOR' named entity 'REGULATED' named entity 'DIVERGENCE' named entity 'ISOLATED' named entity 'IDENTIFIED' named entity 'HIGHLY' covid:arg/1bf6de18aec2c9d092d17543fba178914aca2cfa named entity 'SEQUENCE' named entity 'UNIQUE' named entity 'COUPLED' named entity 'VIRULENCE' named entity 'SUBUNIT' named entity 'PRESENT' named entity 'PATHOGEN' named entity 'RESPIRATORY DISEASE' named entity 'EFFICACY' named entity 'IMPROVED' named entity 'STRAINS' named entity 'ANIMALS' named entity 'OVERALL' named entity 'USED' named entity 'TO DECREASE' named entity 'ANNOTATION' named entity 'LABORATORY' named entity 'MAJORITY' named entity 'SWINE' named entity 'TO IDENTIFY' named entity 'GENOME' named entity 'FIMB' named entity 'REPORTED' named entity 'PREVALENCE' named entity 'GENOMIC' named entity 'HIGHEST' named entity 'REFERENCE' named entity 'PATHOGEN' named entity 'HUMANS' named entity 'GENES' named entity 'RELATIONSHIP' named entity 'CAUSED BY' named entity 'DEVELOPMENT' named entity 'PERSPECTIVE' named entity 'VACCINES' named entity 'STUDY' named entity 'SIMILAR' named entity 'EXPRESSED' named entity 'SEVEN' named entity 'BVGA' named entity 'GENOME SEQUENCE' named entity 'BORDETELLA' named entity 'DISEASE' named entity 'PCR DATA' named entity 'CONTRAST' named entity 'COMPARED'

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