About: Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

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About: Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
Creator	Zhang, Wei Zhu, Tao Hu, Shuo Liu, Zhaoqian Mo, Junluan Yi, Yueneng Yin, Jiye Zheng, Juyan Zhou, Honghao Zhuo, Wei
Source	Medline; PMC
abstract	Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), are involved in mediating fundamental innate antimicrobial immunity by promoting the release of type I interferons (IFNs) and other inflammatory cytokines. Accumulating evidence suggests that the activation of the cGAS-STING axis is critical for antitumor immunity. The downstream cytokines regulated by cGAS-STING, especially type I IFNs, serve as bridges connecting innate immunity with adaptive immunity. Accordingly, a growing number of studies have focused on the synthesis and screening of STING pathway agonists. However, chronic STING activation may lead to a protumor phenotype in certain malignancies. Hence, the cGAS-STING signaling pathway must be orchestrated properly when STING agonists are used alone or in combination. In this review, we discuss the dichotomous roles of the cGAS-STING pathway in tumor development and the latest advances in the use of STING agonists.
has issue date	2020-08-27(xsd:dateTime)
bibo:doi	10.1186/s12943-020-01250-1
bibo:pmid	32854711
has license	cc-by
sha1sum (hex)	1c37e4c3843f6edf3cf055f54f3b97e47a2d9786
schema:url	https://doi.org/10.1186/s12943-020-01250-1
resource representing a document's title	Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
has PubMed Central identifier	PMC7450153
has PubMed identifier	32854711
schema:publication	Mol Cancer
resource representing a document's body	covid:1c37e4c3843f6edf3cf055f54f3b97e47a2d9786#body_text
is schema:about of	named entity 'mechanism' named entity 'cytokines' named entity 'detects' named entity 'innate' named entity 'regulated' named entity 'CGAS' named entity 'MALIGNANCIES' named entity 'TYPE I INTERFERONS' named entity 'CONSERVED' named entity 'AXIS' named entity 'fundamental' named entity 'synthase' named entity 'antimicrobial' named entity 'type I IFNs' named entity 'DNA' named entity 'tumor' named entity 'interferon' named entity 'connecting' named entity 'number' named entity 'properly' named entity 'advances' named entity 'cytokines' named entity 'evolutionarily conserved' named entity 'downstream effector' named entity 'cGAS' named entity 'STING' named entity 'STING' named entity 'cGAS' named entity 'tumor' named entity 'type I IFNs' named entity 'cGAS' named entity 'STING' named entity 'cGAS' named entity 'cGAS' named entity 'cGAMP' named entity 'STING' named entity 'mitochondrial DNA' named entity 'apoptotic cell' named entity 'malignant cells' named entity 'DSDP' named entity 'STING' named entity 'tumor' named entity 'CDNs' named entity 'STING' named entity 'antigen-presenting cells' named entity 'mtDNA' named entity 'cGAS' named entity 'cGAS' named entity 'adaptive immune response' named entity 'tumor cells' named entity 'cGAS-STING' named entity 'colon' named entity 'epithelial cell' named entity 'tumor' named entity 'cell proliferation' named entity 'cell-mediated' named entity 'cell death' named entity 'signaling pathway' named entity 'infection' named entity 'CLL' named entity 'antimicrobial' named entity 'GMP' named entity 'bacteria' named entity 'TBK1' named entity 'STING' named entity 'olaparib' named entity 'cGAS' named entity 'antitumor' named entity 'long-term' named entity 'CTLA-4' named entity 'prostate cancer' named entity 'proinflammatory cytokines'

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