About: Molecular diagnosis of microbial copathogens with influenza A(H1N1)pdm09 in Oaxaca, Mexico

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About: Molecular diagnosis of microbial copathogens with influenza A(H1N1)pdm09 in Oaxaca, Mexico Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular diagnosis of microbial copathogens with influenza A(H1N1)pdm09 in Oaxaca, Mexico
Creator	Real-Najarro, Olga Reséndez-Pérez, Diana Saavedra-Alonso, Santiago Cristina Rodríguez-Padilla, Maria Fernández-Santos, Nadia Rodriguez Perez, Mario Román Ramírez-Palacios, Luis
Source	Medline; PMC
abstract	BACKGROUND: Multiple factors have been associated with the severity of infection by influenza A(H1N1)pdm09. These include H1N1 cases with proven coinfections showing clinical association with bacterial contagions. PURPOSE: The objective was to identify H1N1 and copathogens in the Oaxaca (Mexico) population. A cross-sectional survey was conducted from 2009 to 2012. A total of 88 study patients with confirmed H1N1 by quantitative RT-PCR were recruited. METHODS: Total nucleic acid from clinical samples of study patients was analyzed using a TessArray RPM-Flu microarray assay to identify other respiratory pathogens. RESULTS: High prevalence of copathogens (77.3%; 68 patients harbored one to three pathogens), predominantly from Streptococcus, Haemophilus, Neisseria, and Pseudomonas, were detected. Three patients (3.4%) had four or five respiratory copathogens, whereas others (19.3%) had no copathogens. Copathogenic occurrence with Staphylococcus aureus was 5.7%, Coxsackie virus 2.3%, Moraxella catarrhalis 1.1%, Klebsiella pneumoniae 1.1%, and parainfluenza virus 3 1.1%. The number of patients with copathogens was four times higher to those with H1N1 alone (80.68% and 19.32%, respectively). Four individuals (4.5%; two males, one female, and one infant) who died due to H1N1 were observed to have harbored such copathogens as Streptococcus, Staphylococcus, Haemophilus, and Neisseria. CONCLUSION: In summary, copathogens were found in a significant number (>50%) of cases of influenza in Oaxaca. Timely detection of coinfections producing increased acuity or severity of disease and treatment of affected patients is urgently needed.
has issue date	2018-04-06(xsd:dateTime)
bibo:doi	10.2147/rrtm.s144075
bibo:pmid	30050355
has license	cc-by-nc
sha1sum (hex)	1c3d3ea935a9625190ebf6f76b035999b03e03f0
schema:url	https://doi.org/10.2147/rrtm.s144075
resource representing a document's title	Molecular diagnosis of microbial copathogens with influenza A(H1N1)pdm09 in Oaxaca, Mexico
has PubMed Central identifier	PMC6047622
has PubMed identifier	30050355
schema:publication	Res Rep Trop Med
resource representing a document's body	covid:1c3d3ea935a9625190ebf6f76b035999b03e03f0#body_text
is schema:about of	named entity 'INFLUENZA A' named entity 'MEXICO' named entity 'OAXACA' named entity 'MICROBIAL' named entity 'MOLECULAR DIAGNOSIS' named entity 'diagnosis' named entity 'Oaxaca' named entity 'microbial' named entity 'Mexico' named entity 'influenza B virus' named entity 'H1N1' named entity 'S. pneumoniae' named entity 'GenBank' named entity 'clinical samples' named entity 'antivirals' named entity 'outpatient' named entity 'reagent' named entity 'sanitary conditions' named entity 'S. mitis' named entity 'asthmatic' named entity 'pathogens' named entity 'tachypnea' named entity 'microarray' named entity 'H1N1' named entity 'pathogen' named entity 'S. mitis' named entity 'Oaxaca' named entity 'asthma' named entity 'nasopharynx' named entity 'abdominal pain' named entity 'mutation rate' named entity 'neuraminidase inhibitor' named entity 'virus' named entity 'PCR' named entity 'influenza infection' named entity 'ILI' named entity 'morbidity' named entity 'influenza pandemic' named entity 'PCR' named entity 'Mexico' named entity 'influenza' named entity 'Coxsackie virus' named entity 'coinfections' named entity 'reagent' named entity 'Affymetrix' named entity 'Qiagen' named entity 'Thermo Fisher Scientific' named entity 'H1N1' named entity 'oseltamivir' named entity 'bacterial pathogens' named entity 'N. meningitidis' named entity 'H1N1' named entity 'intensive care' named entity 'plastic' named entity 'pathogens' named entity 'Haemophilus influenzae' named entity 'hybridization' named entity 'S. mitis' named entity 'mortality rates' named entity 'medical services' named entity 'outpatient' named entity 'Netherlands' named entity 'asthmatic' named entity 'H. influenzae' named entity 'pandemic influenza' named entity 'asymptomatic' named entity 'S. mitis' named entity 'immunosuppression' named entity 'H1N1' named entity 'coinfections' named entity 'microarray' named entity 'microarray' named entity 'coinfection' named entity '2.6' named entity 'PCR'

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