About: Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection

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About: Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection
Creator	Cerny, Andreas Affiliations, Bernasconi, Enos Bertoli, Raffaela Ceschi, Alessandro De Gottardi, Andrea De Gottardi Gastroenterology, Hepatology Fratila, Corneliu Gianella, Pietro Magenta, Lorenzo Majno-Hurst, Pietro Vanini, Gianluca
Source	Elsevier; Medline; PMC
abstract	SUMMARY We present here the case of a 62-year-old man, who was referred to the emergency department with fever and cough for 3 days. He underwent liver transplantation 4 years earlier due to HCV and NASH-related cirrhosis with hepatocellular carcinoma. At admission he was in reduced general conditions. Nasopharyngeal smear specimen resulted positive for SARS-CoV-2 infection. Pulmonary low-dose CT-scan revealed bilateral subpleural ground-glass infiltrates. O2 saturation was 93%. A treatment with lopinavir/ritonavir and hydroxychloroquine twice daily was started. The patient received also cefepime and remained in isolation. Seven days later imaging showed a progression of the pulmonary infiltrates. Cefepime was replaced by meropenem. During the following 3 days the fever resolved, and the general conditions of the patient significantly improved. Consequently, treatment with lopinavir/ritonavir and hydroxychloroquine was stopped. The evolution of SARS-CoV-2 interstitial pneumonia in this immunosuppressed patient was moderate to severe and liver injury was not clinically significant. Despite its limitations, this case report confirm that the liver may be only mildly affected during SARS-CoV-2 infection, also in liver transplanted patients. Further studies are needed to assess whether the outcome of SARS-CoV-2 infection is worse in immunosuppressed patients than in the general population.
has issue date	2020-06-10(xsd:dateTime)
bibo:doi	10.1016/j.clinre.2020.05.014
bibo:pmid	32565199
has license	els-covid
sha1sum (hex)	1c6a2e1afd002710e85dad610a9d565a14f204ca
schema:url	https://doi.org/10.1016/j.clinre.2020.05.014
resource representing a document's title	Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection
has PubMed Central identifier	PMC7284277
has PubMed identifier	32565199
schema:publication	Clin Res Hepatol Gastroenterol
resource representing a document's body	covid:1c6a2e1afd002710e85dad610a9d565a14f204ca#body_text
is schema:about of	named entity 'positive' named entity 'management' named entity 'Journal' covid:arg/1c6a2e1afd002710e85dad610a9d565a14f204ca named entity 'HCV' named entity 'cirrhosis' named entity 'SARS-CoV-2' named entity 'referred' named entity 'hepatocellular carcinoma' named entity 'liver transplantation' named entity 'transplanted' named entity 'cough' named entity 'emergency department' named entity 'liver' named entity 'infection' named entity 'SARS-CoV-2' named entity 'Clinical characteristics' named entity 'Respiratory failure' named entity 'SARS-CoV-2' named entity 'CYP3A4' named entity 'SARS-CoV-2' named entity 'diarrhea' named entity 'HCV' named entity 'infection' named entity 'infection' named entity 'arterial hypertension' named entity 'randomized controlled trial' named entity 'case report' named entity 'cirrhosis' named entity 'tocilizumab' named entity 'interstitial pneumonia' named entity 'respiratory rate' named entity 'Ebola virus' named entity 'liver' named entity 'SARS-CoV-2' named entity 'X-ray' named entity 'fever' named entity 'SARS-CoV-2' named entity 'genotype' named entity 'chymotrypsin' named entity 'evolution' named entity 'SARS-CoV-2' named entity 'HIV protease inhibitors' named entity 'COVID' named entity 'cough' named entity 'antiviral activity' named entity 'remdesivir' named entity 'interstitial pneumonia' named entity 'subpleural' named entity 'liver transplant' named entity 'COVID' named entity 'entecavir' named entity 'oxygen saturation' named entity 'lopinavir/ritonavir' named entity 'rosuvastatin' named entity 'transaminases' named entity 'dimers' named entity 'solid organ transplant' named entity 'pathogens' named entity 'SARS-CoV-2' named entity 'Amlodipine' named entity 'COVID' named entity 'infection' named entity 'SOFA score' named entity 'rosuvastatin' named entity 'Cefepime' named entity 'Cefepime' named entity 'CT-scan' named entity 'kidney transplantation' named entity 'general population'

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