About: Viral evasion of intracellular DNA and RNA sensing

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral evasion of intracellular DNA and RNA sensing
Source	Medline; PMC
abstract	The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that are adept at evading or actively suppressing host immunity. Pattern recognition receptors (PRRs) are key components of antiviral immunity that detect conserved molecular features of viral pathogens and initiate signalling that results in the expression of antiviral genes. In this Review, we discuss the strategies that viruses use to escape immune surveillance by key intracellular sensors of viral RNA or DNA, with a focus on RIG-I-like receptors (RLRs), cyclic GMP–AMP synthase (cGAS) and interferon-γ (IFNγ)-inducible protein 16 (IFI16). Such viral strategies include the sequestration or modification of viral nucleic acids, interference with specific post-translational modifications of PRRs or their adaptor proteins, the degradation or cleavage of PRRs or their adaptors, and the sequestration or relocalization of PRRs. An understanding of viral immune-evasion mechanisms at the molecular level may guide the development of vaccines and antivirals.
has issue date	2016-05-13(xsd:dateTime)
bibo:doi	10.1038/nrmicro.2016.45
bibo:pmid	27174148
has license	green-oa
sha1sum (hex)	1cb17fc57f0e112046b9e5d4fee08a4e79827da2
schema:url	https://doi.org/10.1038/nrmicro.2016.45
resource representing a document's title	Viral evasion of intracellular DNA and RNA sensing
has PubMed Central identifier	PMC5072394
has PubMed identifier	27174148
schema:publication	Nature Reviews Microbiology
resource representing a document's body	covid:1cb17fc57f0e112046b9e5d4fee08a4e79827da2#body_text
is schema:about of	named entity 'LGP2' named entity 'viral RNA' named entity 'KSHV' named entity 'viral pathogen' named entity 'vaccination' named entity 'STING' named entity 'restriction factor' named entity 'damage-associated molecular patterns' named entity 'IL-8' named entity 'Intracellular' named entity 'proteasomal degradation' named entity 'RIG-I' named entity 'RIG-I' named entity 'viral entry' named entity 'HIV' named entity 'HCMV' named entity 'hand, foot and mouth disease' named entity 'viral protein' named entity 'PP1α' named entity 'Picornaviridae' named entity 'infection' named entity 'RLR' named entity 'phosphorylation' named entity 'chromosomal' named entity 'MDA5' named entity 'DNA viruses' named entity 'HCMV' named entity 'KSHV' named entity 'flavivirus' named entity 'nucleic acids' named entity 'protease' named entity 'ATPase' named entity 'dsRNA' named entity 'EV71' named entity 'PRRs' named entity 'protein' named entity 'SARS' named entity 'phosphate' named entity 'binding protein' named entity 'RNA viruses' named entity 'STING' named entity 'HCMV' named entity 'stress granules' named entity 'multivesicular bodies' named entity 'Measles virus' named entity 'CARD' named entity 'NLRP3' named entity 'Borna disease virus' named entity 'IL-1β' named entity 'single-stranded RNA' named entity 'IL-18' named entity 'polyomaviruses' named entity 'HSV-1' named entity 'DENV' named entity 'DNA viruses' named entity 'tumour' named entity 'RSV' named entity 'cell types' named entity 'caspase 1' named entity 'protein' named entity 'pathogenicity' named entity 'MAVS' named entity 'viruses' named entity 'host cell' named entity 'RNA' named entity 'IRF3' named entity 'MDA5' named entity 'virus replication' named entity 'virulence' named entity 'autoimmune diseases' named entity 'induce the expression' named entity 'IκB kinase' named entity 'STING' named entity 'gammaherpesviruses' named entity 'PP1α' named entity 'inflammasome' named entity 'pro-inflammatory cytokines' named entity 'IAV' named entity 'viruses' named entity 'cGAS' named entity 'hepatitis B virus' named entity 'proteases'

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