About: Induction of PrP(Sc)-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease

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About: Induction of PrP(Sc)-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Induction of PrP(Sc)-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease
Creator	Potter, Andrew Griebel, Philip Tikoo, Suresh Cashman, Neil Napper, Scott Scruten, Erin Taschuk, Ryan Woodbury, Murray
Source	PMC
abstract	The ongoing epidemic of chronic wasting disease (CWD) within cervid populations indicates the need for novel approaches for disease management. A vaccine that either reduces susceptibility to infection or reduces shedding of prions by infected animals, or a combination of both, could be of benefit for disease control. The development of such a vaccine is challenged by the unique nature of prion diseases and the requirement for formulation and delivery in an oral format for application in wildlife settings. To address the unique nature of prions, our group targets epitopes, termed disease specific epitopes (DSEs), whose exposure for antibody binding depends on disease-associated misfolding of PrP(C) into PrP(Sc). Here, a DSE corresponding to the rigid loop (RL) region, which was immunogenic following parenteral vaccination, was translated into an oral vaccine. This vaccine consists of a replication-incompetent human adenovirus expressing a truncated rabies glycoprotein G recombinant fusion with the RL epitope (hAd5:tgG-RL). Oral immunization of white-tailed deer with hAd5:tgG-RL induced PrP(Sc)-specific systemic and mucosal antibody responses with an encouraging safety profile in terms of no adverse health effects nor prolonged vector shedding. By building upon proven strategies of formulation for wildlife vaccines, these efforts generate a particular PrP(Sc)-specific oral vaccine for CWD as well as providing a versatile platform, in terms of carrier protein and biological vector, for generation of other oral, peptide-based CWD vaccines.
has issue date	2017-10-02(xsd:dateTime)
bibo:doi	10.1080/19336896.2017.1367083
bibo:pmid	28968152
has license	cc-by-nc-nd
sha1sum (hex)	1cfa24297a36bcd526ad00635440d59bce705a17
schema:url	https://doi.org/10.1080/19336896.2017.1367083
resource representing a document's title	Induction of PrP(Sc)-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease
has PubMed Central identifier	PMC5639826
has PubMed identifier	28968152
schema:publication	Prion
resource representing a document's body	covid:1cfa24297a36bcd526ad00635440d59bce705a17#body_text
is schema:about of	named entity 'SYSTEMIC' named entity 'PROVIDING' named entity 'VACCINATION' named entity 'FORMAT' named entity 'PRP' named entity 'HERE' named entity 'EFFECTS' named entity 'PLATFORM' named entity 'SYSTEMIC' named entity 'SCOTT' named entity 'HUMAN ADENOVIRUS' named entity 'DISEASE MANAGEMENT' named entity 'SHEDDING' named entity 'IMMUNOGENIC' named entity 'OUR' named entity 'PROVEN' named entity 'VACCINE' named entity 'REQUIREMENT' named entity 'PROFILE' named entity 'GLYCOPROTEIN G' named entity 'DISEASE' named entity 'ADDRESS' named entity 'APPROACHES' named entity 'SETTINGS' named entity 'REPLICATION' named entity 'FORMULATION' named entity 'DEVELOPMENT' named entity 'RABIES' named entity 'PRIONS' named entity 'ORAL VACCINE' named entity 'STRATEGIES' named entity 'rigid' named entity 'antibody' named entity 'epitope' named entity 'format' named entity 'specific' named entity 'consists' named entity 'epidemic' named entity 'nature' named entity 'systemic' named entity 'prions' named entity 'disease management' named entity 'chronic wasting disease' named entity 'deer' named entity 'TRANSLATED' named entity 'CHRONIC WASTING DISEASE' named entity 'FUSION' named entity 'EITHER' named entity 'PARTICULAR' named entity 'NOVEL' named entity 'WHITE-TAILED DEER' named entity 'SPECIFIC' named entity 'NEED FOR' named entity 'POPULATIONS' named entity 'PROTEIN ' named entity 'DSE' named entity 'REGION' named entity 'RIGID' named entity 'MUCOSAL' named entity 'ORAL VACCINE' named entity 'CHRONIC WASTING DISEASE' named entity 'INDUCTION' named entity 'IMMUNE RESPONSES' named entity 'CERVID' named entity 'SPECIFIC' named entity 'EPITOPES' named entity 'GENERATE' named entity 'TRUNCATED' named entity 'VECTOR' named entity 'WHITE-TAILED DEER' named entity 'INDUCED' named entity 'THESE' named entity 'UNIQUE' named entity 'TERMS'

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