About: Isolation and growth characterization of novel full length and deletion mutant human MERS-CoV strains from clinical specimens collected during 2015

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About: Isolation and growth characterization of novel full length and deletion mutant human MERS-CoV strains from clinical specimens collected during 2015 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Isolation and growth characterization of novel full length and deletion mutant human MERS-CoV strains from clinical specimens collected during 2015
Creator	Zhang, Jing Tong, Suxiang Assiri, Abdullah Lu, Xiaoyan Li, Yan Jokhdar, Hani Watson, John Tamin, Azaibi Tao, Ying Alaifan, Taghreed Altamimi, Asmaa Kamili, Shifaq Queen, Krista Sakthivel, Senthilkumar Paden, Clinton Gerber, Susan Thornburg, Natalie Andres, Erica Alshareef, Ali
Source	Medline; PMC
abstract	Middle East respiratory syndrome (MERS) is a viral respiratory illness first reported in Saudi Arabia in September 2012 caused by the human coronavirus (CoV), MERS-CoV. Using full-genome sequencing and phylogenetic analysis, scientists have identified three clades and multiple lineages of MERS-CoV in humans and the zoonotic host, dromedary camels. In this study, we have characterized eight MERS-CoV isolates collected from patients in Saudi Arabia in 2015. We have performed full-genome sequencing on the viral isolates, and compared them to the corresponding clinical specimens. All isolates were clade B, lineages 4 and 5. Three of the isolates carry deletions located on three independent regions of the genome in the 5′UTR, ORF1a and ORF3. All novel MERS-CoV strains replicated efficiently in Vero and Huh7 cells. Viruses with deletions in the 5′UTR and ORF1a exhibited impaired viral release in Vero cells. These data emphasize the plasticity of the MERS-CoV genome during human infection.
has issue date	2019-11-01(xsd:dateTime)
bibo:doi	10.1099/jgv.0.001334
bibo:pmid	31592752
has license	bronze-oa
sha1sum (hex)	1d025ba6b4a15c9c992d066fa1f923a13f380acb
schema:url	https://doi.org/10.1099/jgv.0.001334
resource representing a document's title	Isolation and growth characterization of novel full length and deletion mutant human MERS-CoV strains from clinical specimens collected during 2015
has PubMed Central identifier	PMC7079693
has PubMed identifier	31592752
schema:publication	Journal of General Virology
resource representing a document's body	covid:1d025ba6b4a15c9c992d066fa1f923a13f380acb#body_text
is schema:about of	named entity 'humans' named entity 'viral' named entity 'collected' named entity 'SAUDI ARABIA' named entity 'INDEPENDENT' named entity 'HAVE' named entity 'ORF3' named entity 'ISOLATES' named entity 'emphasize' named entity 'identified' named entity 'human' named entity '5′UTR' named entity 'patients' named entity 'All' named entity 'viral' named entity 'carry' named entity 'MERS-CoV' named entity 'zoonotic' named entity 'Viruses' named entity 'camels' named entity 'sequencing' named entity 'Isolation' named entity 'length' named entity 'human' named entity '5′UTR' named entity 'genome' named entity 'Huh7' named entity '5′UTR' named entity 'full-genome sequencing' named entity 'release' named entity 'full-genome sequencing' named entity 'Saudi Arabia' named entity 'respiratory illness' named entity 'MERS-CoV' named entity 'CoV' named entity 'MERS-CoV' named entity 'MERS-CoV' covid:arg/1d025ba6b4a15c9c992d066fa1f923a13f380acb named entity 'infection' named entity 'viral' named entity 'MERS-CoV' named entity 'Middle East respiratory syndrome' named entity 'MERS-CoV' named entity 'deletions' named entity 'Vero' named entity 'clades' named entity 'PLASTICITY' named entity 'Saudi Arabia' named entity 'phylogenetic analysis' named entity 'Vero' named entity 'human infection' named entity 'MERS-CoV' named entity 'zoonotic' named entity 'THESE' named entity 'PATIENTS' named entity 'HUH7' named entity 'Viruses' named entity 'MERS' named entity 'clade' named entity 'human coronavirus' named entity 'dromedary camels' named entity 'CLINICAL' named entity 'VIRAL RELEASE'

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