About: Host–microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease

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About: Host–microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Host–microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease
Creator	Adcock, Ian Hansbro, Philip Smits, Hermelijn Hiemstra, Pieter Bracke, Ken Dickson, Robert Stassen, Frank Bartel, Sabine Gosens, Reinoud Krauss-Etschmann, Susanne
Source	PMC
abstract	Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades, the development of novel and effective therapeutic approaches has been slow. However, there is new and increasing evidence that communities of micro-organisms in our body, the human microbiome, are crucially involved in the development and progression of chronic respiratory diseases. Understanding the detailed mechanisms underlying this cross-talk between host and microbiota is critical for development of microbiome- or host-targeted therapeutics and prevention strategies. Here we review and discuss the most recent knowledge on the continuous reciprocal interaction between the host and microbes in health and respiratory disease. Furthermore, we highlight promising developments in microbiome-based therapies and discuss the need to employ more holistic approaches of restoring both the pulmonary niche and the microbial community.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1183/13993003.02320-2019
bibo:pmid	32430415
has license	cc-by-nc
sha1sum (hex)	1d030bbc967a85a8c064c022cbd2939765683951
schema:url	https://doi.org/10.1183/13993003.02320-2019
resource representing a document's title	Host–microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease
has PubMed Central identifier	PMC7439216
has PubMed identifier	32430415
schema:publication	Eur Respir J
resource representing a document's body	covid:1d030bbc967a85a8c064c022cbd2939765683951#body_text
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