About: Increased plasma levels of leukotriene B4 and prostaglandin E2 in cats experimentally inoculated with feline infectious peritonitis virus

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About: Increased plasma levels of leukotriene B4 and prostaglandin E2 in cats experimentally inoculated with feline infectious peritonitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Increased plasma levels of leukotriene B4 and prostaglandin E2 in cats experimentally inoculated with feline infectious peritonitis virus
Creator	Weiss', R
topic	covid:1d158a5a59102664248619e79c9cfb1cc4e6b6f1#this
source	Medline; PMC
abstract	Specific-pathogen-free kittens experimentally infected with feline infectious peritonitis virus (FIPV) subsequently demonstrated increased plasma levels of the arachidonic acid metabolites, leukotriene (LT) B4 and prostaglandin (PG) E2. Significant increases (P<0.025) in LTB4 plasma levels occurred in all (5/5) FIPV-inoculated kittens on postchallenge-exposure days (PCD) 7 and 14 vs PCD 0. Significant increases (P<0.05) in PGE2 plasma levels occurred in 80% (4/5) of FIPV-infected kittens on PCD 7 and 14. Maximal mean plasma levels of LTB4 and PGE2 occurred on PCD 7 (502.5±45.6 pg/ml and 1108.0±247.9 pg/ml, respectively). A positive correlation was found between LTB4 plasma levels and body temperature (r=0.609, P<0.01). Mean survival time in FIPV-inoculated kittens was 19.4±3.2 days. Gross lesions, including peritoneal or pleural effusions (or both) and connective tissue edema, indicated an increased vascular permeability in the FIPV-infected kittens. Histologically, lesions were characterized by pyogranulomatous inflammation. Immunofluorescent studies of tissues from FIPV-infected kittens demonstrated foci of polymorphonuclear leukocytes and FIPV-positive macrophages oriented around dilated blood vessels. Seemingly, arachidonic acid metabolites, including LTB4 or PGE2 released from macrophages, neutrophils or other cells, may be involved in the pathogenesis of FIP vascular and inflammatory lesions and in some of the clinical disease manifestations.
has issue date	1988-01-01(xsd:dateTime)
bibo:doi	10.1007/bf00343250
bibo:pmid	2848354
has license	no-cc
sha1sum (hex)	1d158a5a59102664248619e79c9cfb1cc4e6b6f1
schema:url	https://doi.org/10.1007/bf00343250
resource representing a document's title	Increased plasma levels of leukotriene B4 and prostaglandin E2 in cats experimentally inoculated with feline infectious peritonitis virus
has PubMed Central identifier	PMC7088611
has PubMed identifier	2848354
schema:publication	Vet Res Commun
resource representing a document's body	covid:1d158a5a59102664248619e79c9cfb1cc4e6b6f1#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/1d158a5a59102664248619e79c9cfb1cc4e6b6f1
is schema:about of	named entity 'prostaglandin' named entity 'kittens' named entity 'peritonitis' named entity 'leukotriene B4' covid:arg/1d158a5a59102664248619e79c9cfb1cc4e6b6f1 named entity 'demonstrated' named entity 'virus' named entity 'levels' named entity 'prostaglandin' named entity 'FIPV' named entity 'R. G.' named entity 'leukotriene' named entity 'PCD' named entity 'LTB4' named entity 'feline infectious peritonitis virus' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'PLASMA LEVELS' named entity 'FIP' named entity 'FIPV' named entity 'FIPV' named entity 'mesentery' named entity 'FIPV' named entity 'endogenous pyrogen' named entity 'fever' named entity 'FIPV' named entity 'Sarstedt' named entity 'FIP' named entity 'PGE2' named entity 'FIPV' named entity 'FIP' named entity 'tissue culture' named entity 'central nervous system depression' named entity 'vasomotor' named entity 'dextran' named entity 'FIPV' named entity 'antibody-mediated' named entity 'rectal temperature' named entity 'interleukin' named entity 'inoculum' named entity 'FIP' named entity 'PCD' named entity 'parietal peritoneum' named entity 'macrophages' named entity 'SPF' named entity 'acetone' named entity 'survival time' named entity 'hematoxylin and eosin' named entity 'PGE2' named entity 'edema' named entity 'mesenteric lymph nodes' named entity 'chemotaxis' named entity 'plasma' named entity 'LTB4' named entity 'polymorphonuclear leukocytes' named entity 'edema' named entity 'PGE2' named entity 'neutrophils' named entity 'pleural effusions' named entity 'LTB4' named entity 'plasma' named entity 'kidney' named entity 'IFN' named entity 'external jugular vein' named entity 'LTB4' named entity 'biochemical' named entity 'PGE2' named entity 'lymph nodes' named entity 'thymic' named entity 'LTB4' named entity 'fluorescence' named entity 'chemotactic' named entity 'antigens' named entity 'plasma levels' named entity 'plasma levels' named entity 'FIPV' named entity 'Auburn, AL' named entity 'liquid scintillation counter' named entity 'Detroit' named entity 'tissue damage'

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