About: Attenuated interferon and pro-inflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation

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About: Attenuated interferon and pro-inflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Attenuated interferon and pro-inflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation
Creator	Chan, Jasper Fuk-Woo Yuen, Kwok-Yung Zhou, Jie Zhang, Xi Chu, Hin Wang, Yixin Yang, Dong Shuai, Huiping Yuan, Shuofeng Cai, Jian-Piao Chai, Yue Hou, Yuxin Kong, Hong Yin, Zhang, Anna Yu, Carol Yu, Richard Chan, Woo Fuk, Jasper Hu, Bingjie Huang, Xiner Chak, Andrew Lee, -Yiu Foundation, Shaw Mak, Mei Yuen, Terrence Tsz-Tai
Source	Medline; PMC
abstract	Clinical manifestations of COVID-19 vary from asymptomatic virus shedding, non-specific pharyngitis, to pneumonia with silent hypoxia and respiratory failure. Dendritic cells and macrophages are sentinel cells for innate and adaptive immunity that affect the pathogenesis of SARS and MERS. However, the interplay between SARS-CoV-2 and these cell types remains unknown. Herein, we investigated the infection and host response of monocyte-derived dendritic cells (moDCs) and macrophages (MDMs) infected by SARS-CoV-2. We demonstrated that moDCs and MDMs were permissive to SARS-CoV-2 infection and protein expression but did not support productive virus replication. Importantly, SARS-CoV-2 launched an attenuated interferon response in both cell types. Additionally, SARS-CoV-2 triggered significant pro-inflammatory cytokine/chemokine expression in MDMs but not in moDCs. Further investigations suggested that this attenuated immune response to SARS-CoV-2 in moDCs was associated with viral antagonism of STAT1 phosphorylation. These findings on pathogenesis may explain the mild and insidious course of COVID-19 till late deterioration.
has issue date	2020-06-21(xsd:dateTime)
bibo:doi	10.1093/infdis/jiaa356
bibo:pmid	32563187
has license	no-cc
sha1sum (hex)	1d2f63512b202d3e087baac8c9e9dc4f1181e90e
schema:url	https://doi.org/10.1093/infdis/jiaa356
resource representing a document's title	Attenuated interferon and pro-inflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation
has PubMed Central identifier	PMC7337793
has PubMed identifier	32563187
schema:publication	J Infect Dis
resource representing a document's body	covid:1d2f63512b202d3e087baac8c9e9dc4f1181e90e#body_text
is schema:about of	named entity 'dendritic cells' named entity 'SARS-CoV-2' named entity 'dendritic cells' named entity 'SARS-CoV-2' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'pathogenesis' named entity 'streptomycin' named entity 'control group' named entity 'nonstructural protein' named entity 'human coronaviruses' named entity 'inoculum' named entity 'PerkinElmer' named entity 'SARS-CoV' named entity 'immune defense' named entity 'SARS-CoV' named entity 'interferon' named entity 'multi-organ failure' named entity 'SARS-CoV-2' named entity 'Middle East respiratory syndrome coronavirus' named entity 'SARS-CoV-2' named entity 'coronavirus disease 2019' named entity 'sentinel cell' named entity 'cytokines' named entity 'SARS-CoV-2' named entity 'phosphate-buffered saline' named entity 'macrophage' named entity 'DMEM' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'phosphorylation' named entity 'clinical outcome' named entity 'COVID' named entity 'COVID' named entity 'STAT1' named entity 'Triton X-100' named entity 'RPMI' named entity 'PBMCs' named entity 'SARS-CoV-2' named entity 'secondary antibody' named entity 'chemokines' named entity 'incubation' named entity 'coronaviruses' named entity 'RPMI' named entity 'RT-PCR' named entity 'pro-inflammatory cytokines' named entity 'Thermo Fisher Scientific' named entity 'dysphonia' named entity 'Coronaviruses' named entity 'genome' named entity 'SARS-CoV-2' named entity 'nucleocapsid' named entity 'SARS-CoV-2' named entity 'STAT1' named entity 'standard deviations' named entity 'SARS-CoV-2' named entity 'COVID'

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