About: Neurological disease and encephalitis in cats experimentally infected with Borna disease virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Neurological disease and encephalitis in cats experimentally infected with Borna disease virus
Creator	Bode, L Lundgren, A.-L Bode, · Johannisson, · Lindberg, · Ludwig, · Muluneh, · Rozell, · Zimmermann, W Zimmermann, ·
source	Medline; PMC
abstract	Barrier-bred cats were inoculated intracerebrally with either the rabbit-adapted Borna disease virus (BDV) strain V or a newly isolated feline BDV, obtained from a cat with natural staggering disease (SD). Three out of eight inoculated cats developed neurological signs and non-suppurative encephalitis; all three recovered from the acute stage of disease. Sero-conversion and the development of neutralizing antibodies occurred in all of the virus-inoculated cats. In addition, cats inoculated with feline BDV showed an early peripheral T cell response not present in cats inoculated with BDV strain V, suggesting that the feline virus exerted a more vigorous effect on the immune system. Using immunohistochemistry and a reverse transcriptase-polymerase chain reaction assay, BDV-specific antigen and nucleic acid could be demonstrated in brain samples from each cat with encephalitis, showing that incomplete viral clearance was probably responsible for the maintenance of inflammation. The successful induction of neurological signs and encephalitis in one cat infected with feline BDV, together with the detection of BDV-specific antigen and nucleic acid in the brain, provides strong evidence for the notion that BDV is the etiological agent behind feline SD.
has issue date	1997-01-01(xsd:dateTime)
bibo:doi	10.1007/s004010050630
bibo:pmid	9113204
has license	no-cc
sha1sum (hex)	1d3f2ffc2c9c6d69e7070b9b573d76aef9208fe6
schema:url	https://doi.org/10.1007/s004010050630
resource representing a document's title	Neurological disease and encephalitis in cats experimentally infected with Borna disease virus
has PubMed Central identifier	PMC7086795
has PubMed identifier	9113204
schema:publication	Acta Neuropathol
resource representing a document's body	covid:1d3f2ffc2c9c6d69e7070b9b573d76aef9208fe6#body_text
is schema:about of	named entity 'strain' named entity 'detection' named entity 'samples' named entity 'etiological agent' named entity 'INCOMPLETE' named entity 'RESPONSIBLE' named entity 'ACUTE STAGE' named entity 'EFFECT' named entity 'NOTION' covid:arg/1d3f2ffc2c9c6d69e7070b9b573d76aef9208fe6 named entity 'natural' named entity 'developed' named entity 'notion' named entity 'clearance' named entity 'inoculated' named entity 'brain' named entity 'Three' named entity 'cats' named entity 'responsible' named entity 'strong' named entity 'inoculated' named entity 'infected' named entity 'T cell' named entity 'suppurative' named entity 'antigen' named entity 'encephalitis' named entity 'BDV' named entity 'Borna disease virus' named entity 'BDV' named entity 'neurological signs' named entity 'Sero-conversion' named entity 'BDV' named entity 'neutralizing antibodies' named entity 'feline' named entity 'signs' named entity 'correlation' named entity 'plasma cells' named entity 'cerebral cortex' named entity 'lymphocytes' named entity 'bromodeoxyuridine' named entity 'antibody' named entity 'peripheral blood leukocytes' named entity 'encephalitis' named entity 'microgliosis' named entity 'rabies' named entity 'virus' named entity 'correlation' named entity 'leukocyte' named entity 'infection' named entity 'basal ganglia' named entity 'infection' named entity 'nucleotide' named entity 'cerebral cortex' named entity 'kDa' named entity 'hippocampus' named entity 'brain cells' named entity 'calici' named entity 'kDa' named entity 'light cycle' named entity 'Cat 6' named entity 'infection' named entity 'CSF analysis' named entity 'clinical signs' named entity 'Borna disease virus' named entity 'antigen' named entity 'flow cytometry' named entity 'ABC' named entity 'BDV' named entity 'hippocampal neurons' named entity 'internal capsule' named entity 'infection' named entity 'mandibular gland'

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