About: Putative vaccine breakthrough event associated with heterotypic rotavirus infection in newborn calves, Turkey, 2015

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About: Putative vaccine breakthrough event associated with heterotypic rotavirus infection in newborn calves, Turkey, 2015 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Putative vaccine breakthrough event associated with heterotypic rotavirus infection in newborn calves, Turkey, 2015
Creator	Bányai, Krisztián Alkan, Feray Coskun, Nüvit Karayel, Ilke Marton, Szilvia Fehér, Enikå
Source	Elsevier; Medline; PMC
abstract	Group A rotaviruses (RVA) are regarded as major enteric pathogens of large ruminants, including cattle. Rotavirus vaccines administered to pregnant cows are commonly used to provide passive immunity that protects newborn calves from the clinical disease. In this study we report the detection of RVA from calves with severe diarrhea in a herd regularly vaccinated to prevent enteric infections including RVA. Diarrheic disease was observed in newborn calves aged 4–15 days, with high morbidity and mortality rates, but no diarrhea was seen in adult animals. Rotavirus antigen was detected by enzyme-immunoassay in the intestinal content or the fecal samples of all examined animals. Besides RVA, bovine coronavirus and bovine enteric calicivirus were detected in some samples. Selected RVA strains were characterized by whole genome sequencing. Two strains, RVA/Cow-wt/TUR/Amasya-1/2015/G8P[5] and RVA/Cow-wt/TUR/Amasya-2/2015/G8P[5] were genotyped as G8-P[5]-I2-R2-C2-M2-A3-N2-T6-E2-H3 and showed >99% nucleotide sequence identity among themselves. This genomic constellation is fairly common among bovine RVA strains; however, phylogenetic analysis of the G8 VP7 gene showed close genetic relationship to some European human RVA strains (up to 98.4% nt identity). Our findings is the first indication regarding the circulation of G8 RVA strains in Turkey. Given that the administered RVA vaccines contained type G6 and G10 VP7 antigens some concerns raised with regard to the level of heterotypic protection elicited by the vaccine strains against circulating bovine G8 RVA strains. Enhancement of surveillance of circulating RVA strains in calves across Turkey is needed to support ongoing vaccination programs.
has issue date	2017-01-04(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2016.12.028
bibo:pmid	28284625
has license	no-cc
sha1sum (hex)	1d4026551d877363fa34a6d63dc00dc1369a9381
schema:url	https://doi.org/10.1016/j.vetmic.2016.12.028
resource representing a document's title	Putative vaccine breakthrough event associated with heterotypic rotavirus infection in newborn calves, Turkey, 2015
has PubMed Central identifier	PMC7117445
has PubMed identifier	28284625
schema:publication	Vet Microbiol
resource representing a document's body	covid:1d4026551d877363fa34a6d63dc00dc1369a9381#body_text
is schema:about of	named entity 'HERD' named entity 'CONTAINED' named entity 'HIGH' named entity 'GENETIC' named entity 'PROTECTION' named entity 'IDENTITY' named entity 'FINDINGS' named entity 'WHOLE GENOME SEQUENCING' named entity 'TO SUPPORT' named entity 'ROTAVIRUS VACCINES' named entity 'BOVINE ENTERIC CALICIVIRUS' named entity 'N2-T6' named entity 'TYPE' named entity 'PASSIVE IMMUNITY' named entity 'BUT' named entity 'CHARACTERIZED' named entity 'ANTIGENS' named entity 'LEVEL' named entity 'ROTAVIRUS ANTIGEN' named entity 'VACCINE' named entity 'G10' named entity 'ANIMALS' named entity 'SEEN' named entity 'TURKEY' named entity 'VACCINES' named entity 'STUDY' named entity 'PHYLOGENETIC ANALYSIS' named entity 'TO PROVIDE' named entity 'Rotavirus' named entity 'Given' named entity 'programs' named entity 'circulation' named entity 'vaccines' named entity 'newborn' covid:arg/1d4026551d877363fa34a6d63dc00dc1369a9381 named entity 'ASSOCIATED WITH' named entity 'DIARRHEA' named entity 'PATHOGENS' named entity 'VP7' named entity 'ENTERIC' named entity 'TURKEY' named entity 'NEWBORN' named entity 'EVENT' named entity 'SEVERE DIARRHEA' named entity 'OUR' named entity 'MORTALITY RATES' named entity 'CALVES' named entity 'SURVEILLANCE' named entity 'PROGRAMS' named entity 'HUMAN' named entity 'ELICITED BY' named entity 'REGULARLY' named entity 'SEQUENCE IDENTITY' named entity 'MAJOR' named entity 'COMMON' named entity 'EXAMINED' named entity 'INFECTIONS' named entity 'GENE' named entity 'NUCLEOTIDE SEQUENCE' named entity 'VACCINATED' named entity 'COWS' named entity 'ENHANCEMENT' named entity 'ADMINISTERED' named entity 'BOVINE' named entity 'USED' named entity 'DAYS' named entity 'ROTAVIRUS INFECTION' named entity 'VACCINE' named entity '2015' named entity 'CIRCULATION' named entity 'EUROPEAN' named entity 'OBSERVED' named entity 'INTESTINAL CONTENT' named entity 'CONCERNS' named entity 'GROUP A ROTAVIRUSES' named entity 'INCLUDING'

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