About: CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3

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About: CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3
Creator	Ba, Xueqing Han, Xiaoqing Luan, Tao Shang, Chao Shi, Huifang Sun, Yingying Wang, Dake Zeng, Xianlu
Source	PMC
abstract	Myeloid-derived suppressor cells (MDSCs) comprise a critical component of the tumor environment and CXCR2 reportedly plays a key role in the pathophysiology of various inflammatory diseases. Here, CXCR2 expression on granulocyte and macrophage progenitor cells (GMPs) was found to participate in myeloid cell differentiation within the tumor environment. In CXCR2-deficient tumor-bearing mice, GMPs exhibited fewer macrophage and dendritic cell progenitor cells than wild-type tumor-bearing mice, thereby decreasing monocytic MDSCs (mo-MDSCs) expansion. CXCR2 deficiency increased SAP18 expression in tumor-bearing mice, which reduced STAT3 phosphorylation through restraining ERK1/2 activation. Our findings reveal a critical role for CXCR2 in regulating hematopoietic progenitor cell differentiation under tumor conditions, and SAP18 is a key negative regulator in this process. Thus, inhibiting CXCR2 expression may alter the tumor microenvironment and attenuate tumor progression.
has issue date	2019-08-08(xsd:dateTime)
bibo:doi	10.1038/s41419-019-1837-1
bibo:pmid	31395859
has license	cc-by
sha1sum (hex)	1d4dfd8f156d35544c822aeff4f6b8a02bac8775
schema:url	https://doi.org/10.1038/s41419-019-1837-1
resource representing a document's title	CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3
has PubMed Central identifier	PMC6687752
has PubMed identifier	31395859
schema:publication	Cell Death Dis
resource representing a document's body	covid:1d4dfd8f156d35544c822aeff4f6b8a02bac8775#body_text
is schema:about of	named entity 'STAT3' named entity 'ERK' named entity 'Thus' named entity 'progenitor cells' named entity 'CXCR2' named entity 'macrophage' named entity 'wild-type' named entity 'critical role' named entity 'mice' named entity 'mice' named entity 'CXCR2' named entity 'mice' named entity 'progenitor cells' named entity 'tumor progression' named entity 'STAT3' named entity 'tumor' named entity 'GMPs' named entity 'hematopoietic progenitor cell' named entity 'GMPs' named entity 'ERK' named entity 'CXCR2' named entity 'CXCR2' named entity 'MDSCs' named entity 'MEK1' named entity 'CXCR2' named entity 'serum' named entity 'M-CSF' named entity 'iNOS' named entity 'RNA sequencing' named entity 'transcriptional' named entity 'lysed' named entity 'hematopoietic progenitor cells' named entity 'CXCR2' named entity 'SYBR Green' named entity 'tumor' named entity 'self-renewal' named entity 'centrifugated' named entity 'Germany' named entity 'flow cytometry' named entity 'CXCL2' named entity 'GMPs' named entity 'p38' named entity 'SAP18' named entity '0.01' named entity 'MDSCs' named entity 'mice' named entity 'clone' named entity 'SAP18' named entity 'molecule' named entity 'Santa Cruz Biotechnology' named entity 'tumor' named entity 'HSPCs' named entity 'serum' named entity 'RNA' named entity 'tumor' named entity 'tumor' named entity 'phosphorylation' named entity 'SAP18' named entity 'CXCR2' named entity 'vector' named entity 'tumor' named entity 'CXCR2' named entity 'SAP18' named entity 'GMPs' named entity 'GM-CSF' named entity 'Meis1' named entity 'PI3Kγ' named entity 'tumor' named entity 'CXCL1' named entity 'CD11b' named entity '293T cells' named entity 'HDAC' named entity 'U0126' named entity 'spleen'

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