About: The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7

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About: The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7
Creator	Chen, Sunrui Pan, Qiuwei Wang, Wenshi Xu, Lei Yin, Yuebang »more»
source	PMC
abstract	The eIF4F complex is a translation initiation factor that closely regulates translation in response to a multitude of environmental conditions including viral infection. How translation initiation factors regulate rotavirus infection remains poorly understood. In this study, the knockdown of the components of the eIF4F complex using shRNA and CRISPR/Cas9 were performed, respectively. We have demonstrated that loss-of-function of the three components of eIF4F, including eIF4A, eIF4E and eIF4G, remarkably promotes the levels of rotavirus genomic RNA and viral protein VP4. Consistently, knockdown of the negative regulator of eIF4F and programmed cell death protein 4 (PDCD4) inhibits the expression of viral mRNA and the VP4 protein. Mechanically, we confirmed that the silence of the eIF4F complex suppressed the protein level of IRF1 and IRF7 that exert potent antiviral effects against rotavirus infection. Thus, these results demonstrate that the eIF4F complex is an essential host factor restricting rotavirus replication, revealing new targets for the development of new antiviral strategies against rotavirus infection.
has issue date	2019-03-29(xsd:dateTime)
bibo:doi	10.3390/ijms20071580
bibo:pmid	30934842
has license	cc-by
sha1sum (hex)	1d75590848a42f84359d8ff9631fdc3145efd631
schema:url	https://doi.org/10.3390/ijms20071580
resource representing a document's title	The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7
has PubMed Central identifier	PMC6480131
has PubMed identifier	30934842
schema:publication	Int J Mol Sci
resource representing a document's body	covid:1d75590848a42f84359d8ff9631fdc3145efd631#body_text
is schema:about of	named entity 'IRF1' named entity 'EUKARYOTIC TRANSLATION INITIATION FACTOR 4F COMPLEX' named entity 'RESTRICTS' named entity 'THESE' named entity 'RESTRICTING' »more»

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