About: A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance

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About: A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance
Creator	Digard, Paul Smith, Jacqueline Smith, Nikki Yu, Le Webster, Robert Burt, David Forrest, Heather Danner, Angela Gutowska, Maria Paton, Ian Patrick Seiler, J
source	Medline; PMC
abstract	BACKGROUND: Chickens are susceptible to infection with a limited number of Influenza A viruses and are a potential source of a human influenza pandemic. In particular, H5 and H7 haemagglutinin subtypes can evolve from low to highly pathogenic strains in gallinaceous poultry. Ducks on the other hand are a natural reservoir for these viruses and are able to withstand most avian influenza strains. RESULTS: Transcriptomic sequencing of lung and ileum tissue samples from birds infected with high (H5N1) and low (H5N2) pathogenic influenza viruses has allowed us to compare the early host response to these infections in both these species. Chickens (but not ducks) lack the intracellular receptor for viral ssRNA, RIG-I and the gene for an important RIG-I binding protein, RNF135. These differences in gene content partly explain the differences in host responses to low pathogenic and highly pathogenic avian influenza virus in chicken and ducks. We reveal very different patterns of expression of members of the interferon-induced transmembrane protein (IFITM) gene family in ducks and chickens. In ducks, IFITM1, 2 and 3 are strongly up regulated in response to highly pathogenic avian influenza, where little response is seen in chickens. Clustering of gene expression profiles suggests IFITM1 and 2 have an anti-viral response and IFITM3 may restrict avian influenza virus through cell membrane fusion. We also show, through molecular phylogenetic analyses, that avian IFITM1 and IFITM3 genes have been subject to both episodic and pervasive positive selection at specific codons. In particular, avian IFITM1 showed evidence of positive selection in the duck lineage at sites known to restrict influenza virus infection. CONCLUSIONS: Taken together these results support a model where the IFITM123 protein family and RIG-I all play a crucial role in the tolerance of ducks to highly pathogenic and low pathogenic strains of avian influenza viruses when compared to the chicken. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-015-1778-8) contains supplementary material, which is available to authorized users.
has issue date	2015-08-04(xsd:dateTime)
bibo:doi	10.1186/s12864-015-1778-8
bibo:pmid	26238195
has license	cc-by
sha1sum (hex)	1db4560940a913194230a37755d10fa154b09d15
schema:url	https://doi.org/10.1186/s12864-015-1778-8
resource representing a document's title	A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance
has PubMed Central identifier	PMC4523026
has PubMed identifier	26238195
schema:publication	BMC Genomics
resource representing a document's body	covid:1db4560940a913194230a37755d10fa154b09d15#body_text
is schema:about of	named entity 'DUCKS' named entity 'RESPONSES' named entity 'pathogenic' named entity 'high' named entity 'highly' named entity 'content' named entity 'pathogenic' named entity 'response' named entity 'RIG-I' named entity 'poultry' named entity 'viral' named entity 'withstand' named entity 'model' named entity 'highly' named entity 'CHICKENS' named entity 'SOURCE' named entity 'RIG-I' named entity 'SUSCEPTIBLE' named entity 'REVEAL' named entity 'LOW' named entity 'IFITM1' named entity 'THESE' named entity 'BINDING PROTEIN' named entity 'INFLUENZA INFECTION' named entity 'SUBTYPES' named entity 'SEQUENCING' named entity 'RESULTS' named entity 'NUMBER OF' named entity 'INTRACELLULAR' named entity 'ROLE' named entity 'SUBJECT' named entity 'INFECTION' named entity 'LACK' named entity 'ILEUM' named entity 'POSITIVE SELECTION' named entity 'PLAY' named entity 'AVIAN INFLUENZA' named entity 'PERVASIVE' named entity 'TAKEN' named entity 'CLUSTERING' named entity 'IFITM3' named entity 'REGULATED' named entity 'GENE' named entity 'GENE FAMILY' named entity 'BACKGROUND' named entity 'COMPARATIVE ANALYSIS' named entity 'INDUCED' named entity 'MEMBRANE FUSION' named entity 'PARTICULAR' named entity 'HOST RESPONSE' named entity 'LITTLE' named entity 'INFLUENZA VIRUSES' named entity 'CONTENT' named entity 'DUCK' named entity 'SPECIES' named entity 'DIFFERENT' named entity 'ANTI-VIRAL RESPONSE' named entity 'SUPPORT' named entity 'VIRAL RESISTANCE' named entity 'HOST' named entity 'AVIAN INFLUENZA' named entity 'TOLERANCE' named entity 'HIGH' named entity 'SEEN' named entity 'STRAINS' named entity 'SSRNA' named entity 'CELL MEMBRANE' named entity 'BIRDS' named entity 'HAND' named entity 'KNOWN' named entity 'TO COMPARE'

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