About: Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection

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About: Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection
Creator	Wolf, Jonathan Bowyer, Ruth El-Sayed, Julia Falchi, Mario Freidin, Maxim Ganesh, Sajaysurya Hysi, Pirro Mangino, Massimo Menni, Cristina Moustafa, Spector, Tim Steves, Claire Valdes, Ana Visconti, Alessia
Source	MedRxiv
abstract	Importance: A strategy for preventing further spread of the ongoing COVID-19 epidemic is to detect infections and isolate infected individuals without the need of extensive bio-specimen testing. Objectives: Here we investigate the prevalence of loss of smell and taste among COVID-19 diagnosed individuals and we identify the combination of symptoms, besides loss of smell and taste, most likely to correspond to a positive COVID-19 diagnosis in non-severe cases. Design: Community survey. Setting and Participants: Subscribers of RADAR COVID-19, an app that was launched for use among the UK general population asking about COVID-19 symptoms. Main Exposure: Loss of smell and taste. Main Outcome Measures: COVID-19. Results: Between 24 and 29 March 2020, 1,573,103 individuals reported their symptoms via the app; 26% reported suffering from one or more symptoms of COVID-19. Of those, n=1702 reported having had a RT-PCR COVID-19 test and gave full report on symptoms including loss of smell and taste; 579 were positive and 1123 negative. In this subset, we find that loss of smell and taste were present in 59% of COVID-19 positive individuals compared to 18% of those negative to the test, yielding an odds ratio (OR) of COVID-19 diagnosis of OR[95%CI]=6.59[5.25; 8.27], P= 1.90x10-59 . We also find that a combination of loss of smell and taste, fever, persistent cough, fatigue, diarrhoea, abdominal pain and loss of appetite is predictive of COVID-19 positive test with sensitivity 0.54[0.44; 0.63], specificity 0.86[0.80; 0.90], ROC-AUC 0.77[0.72; 0.82] in the test set, and cross-validation ROC-AUC 0.75[0.72; 0.77]. When applied to the 410,598 individuals reporting symptoms but not formally tested, our model predicted that 13.06%[12.97%;13.15] of these might have been already infected by the virus. Conclusions and Relevance: Our study suggests that loss of taste and smell is a strong predictor of having been infected by the COVID-19 virus. Also, the combination of symptoms that could be used to identify and isolate individuals includes anosmia, fever, persistent cough, diarrhoea, fatigue, abdominal pain and loss of appetite. This is particularly relevant to healthcare and other key workers in constant contact with the public who have not yet been tested for COVID-19.
has issue date	2020-04-07(xsd:dateTime)
bibo:doi	10.1101/2020.04.05.20048421
has license	medrxiv
sha1sum (hex)	1e48223ccda9ec1fa91dc5f2348e40c217c513e7
schema:url	https://doi.org/10.1101/2020.04.05.20048421
resource representing a document's title	Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection
resource representing a document's body	covid:1e48223ccda9ec1fa91dc5f2348e40c217c513e7#body_text
is schema:about of	named entity 'epidemic' named entity 'combination' named entity 'BIOSPECIMEN' named entity 'LOSS OF SMELL' named entity 'TASTE' named entity 'NEED' named entity 'ONGOING' named entity 'STRONG' named entity 'PREDICTOR' named entity 'IS A' named entity 'COMBINATION' named entity 'PREVENTING' named entity 'STRATEGY' named entity 'TESTING' named entity 'ISOLATE' named entity 'EXTENSIVE' named entity 'TO DETECT' named entity 'SPREAD' named entity 'INDIVIDUALS' named entity 'INFECTIONS' named entity 'OTHER SYMPTOMS' named entity 'INFECTED' covid:arg/1e48223ccda9ec1fa91dc5f2348e40c217c513e7 named entity 'testing' named entity 'COVID-19' named entity 'epidemic' named entity 'aetiologies' named entity 'predictive model' named entity 'chest pain' named entity 'cross-validation' named entity 'tested positive for COVID-19' named entity 'medRxiv' named entity 'medRxiv' named entity 'preprint' named entity 'shortness of breath' named entity 'linear model' named entity 'peer-reviewed' named entity 'COVID' named entity 'South Korea' named entity 'correlation' named entity 'anosmia' named entity 'respiratory illness' named entity 'preprint' named entity 'COVID' named entity 'COVID-19' named entity 'loss of appetite' named entity 'vectors' named entity 'screening tool' named entity 'coronaviruses' named entity 'preprint' named entity 'BMI' named entity 'persistent cough' named entity 'tiredness' named entity 'peer-reviewed' named entity 'multiple testing' named entity 'preprint' named entity 'COVID-19 tests' named entity 'COVID' named entity 'general population' named entity 'shortness of breath' named entity 'COVID' named entity 'TwinsUK' named entity 'medRxiv' named entity 'symptom' named entity 'RT-PCR test' named entity 'infection' named entity 'anosmia' named entity 'preprint' named entity 'preprint' named entity 'preprint' named entity 'anosmia' named entity 'peer-reviewed'

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