About: T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner
Creator	Bergthaler, Andreas Merkler, Doron Pinschewer, Daniel Brü, Wolfgang Horvath, Edit Lö Hning, Max Schedensack, Mariann
Source	Medline; PMC
abstract	Viral infection of the central nervous system can lead to disability and death. Yet the majority of viral infections with central nervous system involvement resolve with only mild clinical manifestations, if any. This is generally attributed to efficient elimination of the infection from the brain coverings, i.e. the meninges, ependyma and chorioplexus, which are the primary targets of haematogeneous viral spread. How the immune system is able to purge these structures from viral infection with only minimal detrimental effects is still poorly understood. In the present work we studied how an attenuated lymphocytic choriomeningitis virus can be cleared from the central nervous system in the absence of overt disease. We show that elimination of the virus from brain ependyma, but not from brain parenchyma, could be achieved by a T cell-dependent mechanism operating independently of major histocompatibility class I antigens and perforin. Considering that cytotoxic T lymphocyte-mediated cytotoxicity is a leading cause of viral immunopathology and tissue damage, our findings may explain why the most common viral intruders of the central nervous system rarely represent a serious threat to our health.
has issue date	2010-03-30(xsd:dateTime)
bibo:doi	10.1093/brain/awq028
bibo:pmid	20354003
has license	no-cc
sha1sum (hex)	1e5b64c822f6ad70e721ffbf9436d9661f92bc2e
schema:url	https://doi.org/10.1093/brain/awq028
resource representing a document's title	T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner
has PubMed Central identifier	PMC7110187
has PubMed identifier	20354003
schema:publication	Brain
resource representing a document's body	covid:1e5b64c822f6ad70e721ffbf9436d9661f92bc2e#body_text
is schema:about of	named entity 'JOURNAL ' named entity 'viral infections' named entity 'MHC' named entity 'efficient' named entity 'detrimental' named entity 'manifestations' named entity 'Yet' named entity 'manner' named entity 'SURFACE GLYCOPROTEIN' named entity 'A MAJOR' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'MECHANISM' named entity 'FINDINGS' named entity 'MINIMAL' named entity 'VIRAL' named entity 'CLEARED' named entity 'MHC' named entity 'REPRESENT' named entity 'A T' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'HOW' named entity 'ABSENCE OF' named entity 'INFECTION' named entity 'IMMUNOPATHOLOGY' named entity 'MAJORITY' named entity 'CENTRAL NERVOUS SYSTEM INVOLVEMENT' named entity 'OVERT' named entity 'GENERALLY' named entity 'DISEASE' named entity 'ELIMINATION' named entity 'HISTOCOMPATIBILITY' named entity 'PERFORIN' named entity 'WHY' named entity 'OUR' named entity 'RECOMBINATION' named entity 'BRAIN PARENCHYMA' named entity 'VIRAL CLEARANCE' named entity 'HISTOCOMPATIBILITY' named entity 'RESOLVE' named entity 'MEDIATED' named entity 'LCMV' named entity 'BRAIN' named entity 'MEDIATE' named entity 'T CELLS' named entity 'EPENDYMA' named entity 'BUT' named entity 'NEUROLOGY' named entity 'CLASS I' named entity 'THESE' named entity 'BRAIN EPENDYMA' named entity 'BUT' named entity 'VIRUS' named entity 'ANTIGENS' named entity 'RAG' named entity 'ABBREVIATIONS' named entity 'DEPENDENT' named entity 'THREAT' named entity 'NUCLEOPROTEIN' named entity 'DEATH' named entity 'CAUSE' named entity 'INDEPENDENT' named entity 'VIRAL INFECTIONS' named entity 'MENINGES' named entity 'THE BRAIN' named entity 'TISSUE DAMAGE' named entity 'RECOMBINANT' named entity 'TARGETS' named entity 'OPERATING' named entity 'CYTOTOXIC T LYMPHOCYTE' named entity 'COMMON' named entity 'PURGE' named entity 'POORLY' named entity 'CYTOTOXICITY' named entity 'IS A' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software