About: Growth behavior of bovine herpesvirus-1 in permissive and semi-permissive cells

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About: Growth behavior of bovine herpesvirus-1 in permissive and semi-permissive cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Growth behavior of bovine herpesvirus-1 in permissive and semi-permissive cells
Creator	Takashima, Yasuhiro Murata, Takayuki Otsuka, Haruki Xuan, Xuen
Source	Elsevier; Medline; PMC
abstract	Abstract Bovine herpesvirus-1 (BHV-1) can replicate well in bovine-derived cell lines such as Madin Darby bovine kidney (MDBK) but grows poorly in hamster lung (HmLu-1). Virus replication, DNA synthesis, and immediate-early gene expression are severely restricted in HmLu-1. We compared adsorption and penetration of BHV-1 in permissive MDBK and semi-permissive HmLu-1 cells. At a low multiplicity of infection, BHV-1 attached to permissive MDBK cells twice as much as to HmLu-1. The presence of heparin inhibited the attachment of BHV-1 to MDBK cells by about 60%, but over 90% of the attachment was inhibited in HmLu-1. To investigate the penetration of BHV-1, we performed the quantitative measurement of viral DNA by quantitative competitive (QC)PCR in infected cells. In MDBK cells, virions attached to the cell surface, penetrated into the cells and were transported to the nucleus. However in HmLu-1, only a small fraction of the virions attached to the cell surface were allowed to penetrate. Our results indicated that the replication of BHV-1 in semi-permissive HmLu-1 was not dramatically restricted at one certain point but at some various stages including adsorption and penetration.
has issue date	1999-05-31(xsd:dateTime)
bibo:doi	10.1016/s0168-1702(99)00023-4
bibo:pmid	10426207
has license	els-covid
sha1sum (hex)	1ed5aa872a1285ffe83056419c860142c8710d89
schema:url	https://doi.org/10.1016/s0168-1702%2899%2900023-4
resource representing a document's title	Growth behavior of bovine herpesvirus-1 in permissive and semi-permissive cells
has PubMed Central identifier	PMC7125965
has PubMed identifier	10426207
schema:publication	Virus Research
resource representing a document's body	covid:1ed5aa872a1285ffe83056419c860142c8710d89#body_text
is schema:about of	named entity 'cells' named entity 'Bovine' named entity 'replicate' named entity 'Growth' named entity '90%' named entity 'DNA SYNTHESIS' named entity 'POINT' named entity 'POORLY' named entity 'COMPARED' named entity 'RESTRICTED' named entity 'ADSORPTION' named entity 'CELL LINES' named entity 'MUCH' named entity 'TO INVESTIGATE' named entity 'PENETRATE' named entity 'SMALL' named entity 'ATTACHMENT' named entity 'LOW' named entity 'VIRIONS' named entity 'VARIOUS' named entity 'LUNG' named entity 'KIDNEY' named entity 'ABOUT' named entity 'PENETRATION' named entity 'BOVINE' named entity 'REPLICATION' named entity 'RESULTS' named entity 'BOVINE HERPESVIRUS-1' named entity 'GROWTH BEHAVIOR' named entity 'MDBK' named entity 'NUCLEUS' named entity 'INHIBITED' named entity 'ALLOWED' named entity 'FRACTION OF' named entity 'HEPARIN' named entity 'CELL SURFACE' named entity 'IMMEDIATE-EARLY GENE' named entity 'GENE EXPRESSION' named entity 'MULTIPLICITY' named entity 'MEASUREMENT' named entity 'ATTACHED TO' named entity 'PERFORMED' named entity 'INDICATED' named entity 'DERIVED' named entity 'TWICE' named entity 'VIRUS REPLICATION' named entity 'QUANTITATIVE' named entity 'REPLICATE' named entity 'HAMSTER' named entity 'BUT' named entity 'SEVERELY' named entity 'BHV-1' named entity 'COMPETITIVE' named entity 'VIRAL DNA' named entity 'PENETRATED' named entity '60%' named entity 'INCLUDING' named entity 'PRESENCE OF' named entity 'OUR' named entity 'INFECTED' named entity 'CELLS' named entity 'INFECTION' named entity 'CERTAIN' named entity 'CELLS' named entity 'STAGES' named entity 'BOVINE HERPESVIRUS-1' covid:arg/1ed5aa872a1285ffe83056419c860142c8710d89 named entity 'Darby' named entity 'cell' named entity 'kidney' named entity 'BHV' named entity 'viral' named entity 'nucleus' named entity 'competitive' named entity 'BHV-1' named entity 'cell surface' named entity 'cell lines' named entity 'virions'

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