About: Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model
Creator	Zompi, Simona Blomberg, Jonas Elfaitouri, Amal Gottfries, Carl-Gerhard Rizwan, Muhammad Rosén, Anders Denmark, Deaunne Hanson, Maureen
source	Medline; PMC
abstract	Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent findings and placed them in the context of the clinical picture and natural history of the disease. A pattern emerged, giving rise to an explanatory model. ME/CFS often starts after or during an infection. A logical explanation is that the infection initiates an autoreactive process, which affects several functions, including brain and energy metabolism. According to our model for ME/CFS pathogenesis, patients with a genetic predisposition and dysbiosis experience a gradual development of B cell clones prone to autoreactivity. Under normal circumstances these B cell offsprings would have led to tolerance. Subsequent exogenous microbial exposition (triggering) can lead to comorbidities such as fibromyalgia, thyroid disorder, and orthostatic hypotension. A decisive infectious trigger may then lead to immunization against autoantigens involved in aerobic energy production and/or hormone receptors and ion channel proteins, producing postexertional malaise and ME/CFS, affecting both muscle and brain. In principle, cloning and sequencing of immunoglobulin variable domains could reveal the evolution of pathogenic clones. Although evidence consistent with the model accumulated in recent years, there are several missing links in it. Hopefully, the hypothesis generates testable propositions that can augment the understanding of the pathogenesis of ME/CFS.
has issue date	2018-02-15(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.00229
bibo:pmid	29497420
has license	cc-by
sha1sum (hex)	1ed7ba58402344abc5e614e344d03a30c03164af
schema:url	https://doi.org/10.3389/fimmu.2018.00229
resource representing a document's title	Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model
has PubMed Central identifier	PMC5818468
has PubMed identifier	29497420
schema:publication	Front Immunol
resource representing a document's body	covid:1ed7ba58402344abc5e614e344d03a30c03164af#body_text
is schema:about of	named entity 'MODEL' named entity 'FATIGUE' named entity 'ELICITED' named entity 'MYALGIC ENCEPHALOMYELITIS' named entity 'INFECTION' named entity 'EXPLANATORY' named entity 'AUTOIMMUNITY' named entity 'SYNDROME' named entity 'autoantigen' named entity 'thiobarbituric acid reactive substances' named entity 'biomarker' named entity 'NADPH' named entity 'malaise' named entity 'ME/CFS' named entity 'pyruvate kinase' named entity 'SLE' named entity 'immunoglobulin gene' named entity 'cytokine' named entity 'ME/CFS' named entity 'peroxisomes' named entity 'Ebola' named entity 'glutathione' named entity 'carbon metabolism' named entity 'Infection' named entity 'pyruvate' named entity 'ME/CFS' named entity 'danger-associated molecular patterns' named entity 'carbon metabolism' named entity 'aerobic' named entity 'cerebrospinal fluid' named entity 'physical activity' named entity 'TNFα' named entity 'Rituximab' named entity 'chronic fatigue syndrome' named entity 'genetic predisposition' named entity 'autoimmunity' named entity 'epigenetic' named entity 'ME/CFS' named entity 'carbon metabolism' named entity 'IL35' named entity 'autoimmune disease' named entity 'lymphomas' named entity 'POTS' named entity 'posttranslationally' named entity 'leukocyte' named entity 'psychosomatic' named entity 'energy metabolism' named entity 'vaccination' named entity 'fever' named entity 'gut microbiome' named entity 'Novosphingobium' named entity 'regulatory RNAs' named entity 'ME/CFS' named entity 'diagnostic tests' named entity 'oxygen' named entity 'B12' named entity 'Metabolic disturbances' named entity 'epidemic' named entity 'ME/CFS' named entity 'epidemiological studies' named entity 'viral proteins' named entity 'lipoic acid' named entity 'HSP70' named entity 'autoantibodies' named entity 'patHoGenesis' named entity 'pathogenetic' named entity 'cell clones' named entity 'hormone' named entity 'autoimmune disease' named entity 'clinical examination' named entity 'ME/CFS' named entity 'Behcet's syndrome' named entity 'cytokine' named entity 'autoimmune condition'

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