About: New classes of Gram-positive selective antibacterials: Inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis

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About: New classes of Gram-positive selective antibacterials: Inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	New classes of Gram-positive selective antibacterials: Inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis
Creator	Cook, James Engelbrecht, Kathleen Ignasiak, Rachel Monte, Aaron Polanowski, Rebecca Rott, Marc Sherman, David Krueger, Sarah Reed, Kurt Schwan, William Shahjahan Kabir, M Stemper, Mary
source	Elsevier; Medline; PMC
abstract	Abstract An antimicrobial phenolic stilbene, (E)-3-hydroxy-5-methoxystilbene, 1 was recently isolated from the leaves of Comptonia peregrina (L.) Coulter and shown to possess inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillus anthracis (Sterne strain), among others. These results prompted the design and synthesis of two new classes of compounds, phenoxystyrenes and phenothiostyrenes, as analogs of the natural antimicrobial stilbene. These and additional stilbenoid analogs were synthesized using new, efficient, copper-mediated coupling strategies. Minimum inhibitory concentration (MIC) antimicrobial assays were performed on all compounds prepared. These preliminary structure–activity relationship studies indicated that both new classes of synthetic analogs, as well as the stilbenes, show promising activity against Gram-positive bacteria when at least one phenolic moiety is present, but not when absent. The potencies of the phenolic phenoxystyrenes and phenothiostyrenes were found to be comparable to those of the phenolic stilbenes tested.
has issue date	2008-11-01(xsd:dateTime)
bibo:doi	10.1016/j.bmcl.2008.09.085
bibo:pmid	18849164
has license	els-covid
sha1sum (hex)	1ef3be3443da57bba760d29bcdbfc399ddd5fbde
schema:url	https://doi.org/10.1016/j.bmcl.2008.09.085
resource representing a document's title	New classes of Gram-positive selective antibacterials: Inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis
has PubMed Central identifier	PMC7127099
has PubMed identifier	18849164
schema:publication	Bioorganic & Medicinal Chemistry Letters
resource representing a document's body	covid:1ef3be3443da57bba760d29bcdbfc399ddd5fbde#body_text
is schema:about of	named entity 'GRAM-' named entity 'causative' named entity 'MRSA' named entity 'Gram-positive' named entity 'TUBERCULOSIS' named entity 'ANTIBACTERIALS' named entity 'TEL' named entity '2B1' named entity 'SELECTIVE' named entity 'INHIBITORS' named entity 'CAUSATIVE AGENTS' named entity 'CLASSES' named entity 'MRSA' named entity 'FAX' named entity '28A' named entity '8281' named entity 'COOK' named entity '608' named entity 'POSITIVE' named entity '8260' named entity 'MONTE' named entity 'NEW' named entity 'ANTHRAX' named entity '3,5' named entity 'antimicrobial agents' named entity 'methoxy groups' named entity 'MIC' named entity 'stilbene' named entity 'biological activity' named entity 'inhibitory activity' named entity 'phenolic' named entity 'trans' named entity 'S. aureus' named entity 'Resveratrol' named entity 'phenolic' named entity 'stilbenes' named entity 'cytoxic' named entity 'class of compounds' named entity 'stilbenoid' named entity 'enzyme inhibition' named entity 'clinically significant' named entity 'antibacterial activity' named entity 'Bacillus anthracis' named entity 'North American' named entity 'MIC' named entity 'antimicrobial' named entity 'THF' named entity 'medicinal plants' named entity 'M. smegmatis' named entity 'Bacillus' named entity 'Gram-positive' named entity 'antimicrobial activity' named entity 'phenolic' named entity 'stilbenes' named entity 'minimum inhibitory concentration' named entity 'chemotherapeutic agents' named entity 'Bacillus' named entity 'Bacillus cereus' named entity 'cancer cell lines' named entity 'selective' named entity 'fax' named entity 'Gram-positive' named entity 'MRSA' named entity 'antibacterials' named entity 'B. anthracis' named entity 'methicillin-resistant Staphylococcus aureus' named entity 'clinically relevant' named entity 'anthrax' named entity 'methyl' named entity 'Comptonia peregrina'

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